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Hematopoietic niche drives FLT3-ITD acute myeloid leukemia resistance to quizartinib via STAT5-and hypoxia-dependent upregulation of AXL.
Dumas PY, Naudin C, Martin-Lannerée S, Izac B, Casetti L, Mansier O, Rousseau B, Artus A, Dufossée M, Giese A, Dubus P, Pigneux A, Praloran V, Bidet A, Villacreces A, Guitart A, Milpied N, Kosmider O, Vigon I, Desplat V, Dusanter-Fourt I, Pasquet JM. Dumas PY, et al. Among authors: izac b. Haematologica. 2019 Oct;104(10):2017-2027. doi: 10.3324/haematol.2018.205385. Epub 2019 Mar 28. Haematologica. 2019. PMID: 30923103 Free PMC article. Clinical Trial.
Expression of Pitx2 in stromal cells is required for normal hematopoiesis.
Kieusseian A, Chagraoui J, Kerdudo C, Mangeot PE, Gage PJ, Navarro N, Izac B, Uzan G, Forget BG, Dubart-Kupperschmitt A. Kieusseian A, et al. Among authors: izac b. Blood. 2006 Jan 15;107(2):492-500. doi: 10.1182/blood-2005-02-0529. Epub 2005 Sep 29. Blood. 2006. PMID: 16195330 Free PMC article.
35 results