Iyer S - Search Results

1

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation.

Robin AY, Miller MS, Iyer S, Shi MX, Wardak AZ, Lio D, Smith NA, Smith BJ, Birkinshaw RW, Czabotar PE, Kluck RM, Colman PM. Robin AY, et al. Among authors: iyer s. Cell Death Differ. 2022 Sep;29(9):1757-1768. doi: 10.1038/s41418-022-00961-w. Epub 2022 Mar 12. Cell Death Differ. 2022. PMID: 35279694 Free PMC article.

2

Bax targets mitochondria by distinct mechanisms before or during apoptotic cell death: a requirement for VDAC2 or Bak for efficient Bax apoptotic function.

Ma SB, Nguyen TN, Tan I, Ninnis R, Iyer S, Stroud DA, Menard M, Kluck RM, Ryan MT, Dewson G. Ma SB, et al. Among authors: iyer s. Cell Death Differ. 2014 Dec;21(12):1925-35. doi: 10.1038/cdd.2014.119. Epub 2014 Aug 22. Cell Death Differ. 2014. PMID: 25146925 Free PMC article.

3

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.

Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM, Kluck RM. Westphal D, et al. Among authors: iyer s. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4076-85. doi: 10.1073/pnas.1415142111. Epub 2014 Sep 16. Proc Natl Acad Sci U S A. 2014. PMID: 25228770 Free PMC article.

4

Bak apoptotic pores involve a flexible C-terminal region and juxtaposition of the C-terminal transmembrane domains.

Iyer S, Bell F, Westphal D, Anwari K, Gulbis J, Smith BJ, Dewson G, Kluck RM. Iyer S, et al. Cell Death Differ. 2015 Oct;22(10):1665-75. doi: 10.1038/cdd.2015.15. Epub 2015 Mar 6. Cell Death Differ. 2015. PMID: 25744027 Free PMC article.

5

Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.

Iyer S, Anwari K, Alsop AE, Yuen WS, Huang DC, Carroll J, Smith NA, Smith BJ, Dewson G, Kluck RM. Iyer S, et al. Nat Commun. 2016 May 24;7:11734. doi: 10.1038/ncomms11734. Nat Commun. 2016. PMID: 27217060 Free PMC article.

6

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization.

Brasacchio D, Alsop AE, Noori T, Lufti M, Iyer S, Simpson KJ, Bird PI, Kluck RM, Johnstone RW, Trapani JA. Brasacchio D, et al. Among authors: iyer s. Cell Death Differ. 2017 Jun;24(6):961-970. doi: 10.1038/cdd.2016.119. Epub 2017 Jan 6. Cell Death Differ. 2017. PMID: 28060382 Free PMC article.

7

Disordered clusters of Bak dimers rupture mitochondria during apoptosis.

Uren RT, O'Hely M, Iyer S, Bartolo R, Shi MX, Brouwer JM, Alsop AE, Dewson G, Kluck RM. Uren RT, et al. Among authors: iyer s. Elife. 2017 Feb 6;6:e19944. doi: 10.7554/eLife.19944. Elife. 2017. PMID: 28182867 Free PMC article.

8

Pore formation by dimeric Bak and Bax: an unusual pore?

Uren RT, Iyer S, Kluck RM. Uren RT, et al. Among authors: iyer s. Philos Trans R Soc Lond B Biol Sci. 2017 Aug 5;372(1726):20160218. doi: 10.1098/rstb.2016.0218. Philos Trans R Soc Lond B Biol Sci. 2017. PMID: 28630157 Free PMC article. Review.

9

Ensemble Properties of Bax Determine Its Function.

Robin AY, Iyer S, Birkinshaw RW, Sandow J, Wardak A, Luo CS, Shi M, Webb AI, Czabotar PE, Kluck RM, Colman PM. Robin AY, et al. Among authors: iyer s. Structure. 2018 Oct 2;26(10):1346-1359.e5. doi: 10.1016/j.str.2018.07.006. Epub 2018 Aug 16. Structure. 2018. PMID: 30122452 Free article.

10

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.

Iyer S, Uren RT, Kluck RM. Iyer S, et al. Methods Mol Biol. 2019;1877:201-216. doi: 10.1007/978-1-4939-8861-7_14. Methods Mol Biol. 2019. PMID: 30536008

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