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Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity.
Iyer KR, Li SC, Revie NM, Lou JW, Duncan D, Fallah S, Sanchez H, Skulska I, Ušaj MM, Safizadeh H, Larsen B, Wong C, Aman A, Kiyota T, Yoshimura M, Kimura H, Hirano H, Yoshida M, Osada H, Gingras AC, Andes DR, Shapiro RS, Robbins N, Mazhab-Jafari MT, Whitesell L, Yashiroda Y, Boone C, Cowen LE. Iyer KR, et al. Cell Chem Biol. 2023 Jul 20;30(7):795-810.e8. doi: 10.1016/j.chembiol.2023.06.005. Epub 2023 Jun 26. Cell Chem Biol. 2023. PMID: 37369212 Free PMC article.
Antifungal drug resistance: evolution, mechanisms and impact.
Revie NM, Iyer KR, Robbins N, Cowen LE. Revie NM, et al. Among authors: iyer kr. Curr Opin Microbiol. 2018 Oct;45:70-76. doi: 10.1016/j.mib.2018.02.005. Epub 2018 Mar 13. Curr Opin Microbiol. 2018. PMID: 29547801 Free PMC article. Review.
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2.
Caplan T, Lorente-Macías Á, Stogios PJ, Evdokimova E, Hyde S, Wellington MA, Liston S, Iyer KR, Puumala E, Shekhar-Guturja T, Robbins N, Savchenko A, Krysan DJ, Whitesell L, Zuercher WJ, Cowen LE. Caplan T, et al. Among authors: iyer kr. Cell Chem Biol. 2020 Mar 19;27(3):269-282.e5. doi: 10.1016/j.chembiol.2019.12.008. Epub 2020 Jan 7. Cell Chem Biol. 2020. PMID: 31924499 Free PMC article.
Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets.
Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE. Fu C, et al. Among authors: iyer kr. Nat Commun. 2021 Nov 11;12(1):6497. doi: 10.1038/s41467-021-26850-3. Nat Commun. 2021. PMID: 34764269 Free PMC article.
80 results