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Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.
Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J. Slagboom J, et al. Among authors: iyer j. Toxicon. 2018 Jun 15;148:213-222. doi: 10.1016/j.toxicon.2018.04.022. Epub 2018 May 4. Toxicon. 2018. PMID: 29730150 Free article.
Avathrin: a novel thrombin inhibitor derived from a multicopy precursor in the salivary glands of the ixodid tick, Amblyomma variegatum.
Iyer JK, Koh CY, Kazimirova M, Roller L, Jobichen C, Swaminathan K, Mizuguchi J, Iwanaga S, Nuttall PA, Chan MY, Kini RM. Iyer JK, et al. FASEB J. 2017 Jul;31(7):2981-2995. doi: 10.1096/fj.201601216R. Epub 2017 Mar 31. FASEB J. 2017. PMID: 28363953
Such precursor proteins that could be processed into multiple thrombin inhibiting peptides appear to be widespread among Amblyomminae, providing an enormous library of molecules for development as potent antithrombotics.-Iyer, J. K., Koh, C. Y., Kazimirova, M., Roll …
Such precursor proteins that could be processed into multiple thrombin inhibiting peptides appear to be widespread among Amblyomminae, provi …
Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors.
Koh CY, Shih N, Yip CYC, Li AWL, Chen W, Amran FS, Leong EJE, Iyer JK, Croft G, Mazlan MIB, Chee YL, Yap ES, Monroe DM, Hoffman M, Becker RC, de Kleijn DPV, Verma V, Gupta A, Chaudhary VK, Richards AM, Kini RM, Chan MY. Koh CY, et al. Nat Commun. 2021 Nov 25;12(1):6912. doi: 10.1038/s41467-021-27275-8. Nat Commun. 2021. PMID: 34824278 Free PMC article.
Electron microscopy examination of platelet whole mount preparations to quantitate platelet dense granule numbers: Implications for diagnosing suspected platelet function disorders due to dense granule deficiency.
Brunet JG, Iyer JK, Badin MS, Graf L, Moffat KA, Timleck M, Spitzer E, Hayward CPM. Brunet JG, et al. Among authors: iyer jk. Int J Lab Hematol. 2018 Aug;40(4):400-407. doi: 10.1111/ijlh.12801. Epub 2018 Mar 6. Int J Lab Hematol. 2018. PMID: 29508516
Bleeding risks for uncharacterized platelet function disorders.
Brunet J, Badin M, Chong M, Iyer J, Tasneem S, Graf L, Rivard GE, Paterson AD, Pare G, Hayward CPM. Brunet J, et al. Among authors: iyer j. Res Pract Thromb Haemost. 2020 May 30;4(5):799-806. doi: 10.1002/rth2.12374. eCollection 2020 Jul. Res Pract Thromb Haemost. 2020. PMID: 32685888 Free PMC article.
224 results