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Hepatocyte ELOVL Fatty Acid Elongase 6 Determines Ceramide Acyl-Chain Length and Hepatic Insulin Sensitivity in Mice.
Matsuzaka T, Kuba M, Koyasu S, Yamamoto Y, Motomura K, Arulmozhiraja S, Ohno H, Sharma R, Shimura T, Okajima Y, Han SI, Aita Y, Mizunoe Y, Osaki Y, Iwasaki H, Yatoh S, Suzuki H, Sone H, Takeuchi Y, Yahagi N, Miyamoto T, Sekiya M, Nakagawa Y, Ema M, Takahashi S, Tokiwa H, Shimano H. Matsuzaka T, et al. Among authors: iwasaki h. Hepatology. 2020 May;71(5):1609-1625. doi: 10.1002/hep.30953. Epub 2020 Feb 7. Hepatology. 2020. PMID: 31529722
Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.
Matsuzaka T, Shimano H, Yahagi N, Kato T, Atsumi A, Yamamoto T, Inoue N, Ishikawa M, Okada S, Ishigaki N, Iwasaki H, Iwasaki Y, Karasawa T, Kumadaki S, Matsui T, Sekiya M, Ohashi K, Hasty AH, Nakagawa Y, Takahashi A, Suzuki H, Yatoh S, Sone H, Toyoshima H, Osuga J, Yamada N. Matsuzaka T, et al. Among authors: iwasaki h, iwasaki y. Nat Med. 2007 Oct;13(10):1193-202. doi: 10.1038/nm1662. Epub 2007 Sep 30. Nat Med. 2007. PMID: 17906635
Nuclear SREBP-1a causes loss of pancreatic beta-cells and impaired insulin secretion.
Iwasaki Y, Iwasaki H, Yatoh S, Ishikawa M, Kato T, Matsuzaka T, Nakagawa Y, Yahagi N, Kobayashi K, Takahashi A, Suzuki H, Yamada N, Shimano H. Iwasaki Y, et al. Among authors: iwasaki h. Biochem Biophys Res Commun. 2009 Jan 16;378(3):545-50. doi: 10.1016/j.bbrc.2008.11.105. Epub 2008 Dec 3. Biochem Biophys Res Commun. 2009. PMID: 19056350
Sterol regulatory element-binding protein-1 determines plasma remnant lipoproteins and accelerates atherosclerosis in low-density lipoprotein receptor-deficient mice.
Karasawa T, Takahashi A, Saito R, Sekiya M, Igarashi M, Iwasaki H, Miyahara S, Koyasu S, Nakagawa Y, Ishii K, Matsuzaka T, Kobayashi K, Yahagi N, Takekoshi K, Sone H, Yatoh S, Suzuki H, Yamada N, Shimano H. Karasawa T, et al. Among authors: iwasaki h. Arterioscler Thromb Vasc Biol. 2011 Aug;31(8):1788-95. doi: 10.1161/ATVBAHA.110.219659. Epub 2011 May 5. Arterioscler Thromb Vasc Biol. 2011. PMID: 21546605
Macrophage Elovl6 deficiency ameliorates foam cell formation and reduces atherosclerosis in low-density lipoprotein receptor-deficient mice.
Saito R, Matsuzaka T, Karasawa T, Sekiya M, Okada N, Igarashi M, Matsumori R, Ishii K, Nakagawa Y, Iwasaki H, Kobayashi K, Yatoh S, Takahashi A, Sone H, Suzuki H, Yahagi N, Yamada N, Shimano H. Saito R, et al. Among authors: iwasaki h. Arterioscler Thromb Vasc Biol. 2011 Sep;31(9):1973-9. doi: 10.1161/ATVBAHA.110.221663. Epub 2011 Aug 4. Arterioscler Thromb Vasc Biol. 2011. PMID: 21817094
Inhibition of ubiquitin ligase F-box and WD repeat domain-containing 7α (Fbw7α) causes hepatosteatosis through Krüppel-like factor 5 (KLF5)/peroxisome proliferator-activated receptor γ2 (PPARγ2) pathway but not SREBP-1c protein in mice.
Kumadaki S, Karasawa T, Matsuzaka T, Ema M, Nakagawa Y, Nakakuki M, Saito R, Yahagi N, Iwasaki H, Sone H, Takekoshi K, Yatoh S, Kobayashi K, Takahashi A, Suzuki H, Takahashi S, Yamada N, Shimano H. Kumadaki S, et al. Among authors: iwasaki h. J Biol Chem. 2011 Nov 25;286(47):40835-46. doi: 10.1074/jbc.M111.235283. Epub 2011 Sep 12. J Biol Chem. 2011. PMID: 21911492 Free PMC article.
TFE3 regulates muscle metabolic gene expression, increases glycogen stores, and enhances insulin sensitivity in mice.
Iwasaki H, Naka A, Iida KT, Nakagawa Y, Matsuzaka T, Ishii KA, Kobayashi K, Takahashi A, Yatoh S, Yahagi N, Sone H, Suzuki H, Yamada N, Shimano H. Iwasaki H, et al. Am J Physiol Endocrinol Metab. 2012 Apr 1;302(7):E896-902. doi: 10.1152/ajpendo.00204.2011. Epub 2012 Jan 31. Am J Physiol Endocrinol Metab. 2012. PMID: 22297304 Free article.
Dicer has a crucial role in the early stage of adipocyte differentiation, but not in lipid synthesis, in 3T3-L1 cells.
Fujimoto Y, Nakagawa Y, Shingyouchi A, Tokushige N, Nakanishi N, Satoh A, Matsuzaka T, Ishii KA, Iwasaki H, Kobayashi K, Yatoh S, Suzuki H, Yahagi N, Urayama O, Yamada N, Shimano H. Fujimoto Y, et al. Among authors: iwasaki h. Biochem Biophys Res Commun. 2012 Apr 20;420(4):931-6. doi: 10.1016/j.bbrc.2012.03.110. Epub 2012 Mar 26. Biochem Biophys Res Commun. 2012. PMID: 22475483
TFE3 inhibits myoblast differentiation in C2C12 cells via down-regulating gene expression of myogenin.
Naka A, Iida KT, Nakagawa Y, Iwasaki H, Takeuchi Y, Satoh A, Matsuzaka T, Ishii KA, Kobayashi K, Yatoh S, Shimada M, Yahagi N, Suzuki H, Sone H, Yamada N, Shimano H. Naka A, et al. Among authors: iwasaki h. Biochem Biophys Res Commun. 2013 Jan 11;430(2):664-9. doi: 10.1016/j.bbrc.2012.11.094. Epub 2012 Dec 2. Biochem Biophys Res Commun. 2013. PMID: 23211595
2,396 results