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Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.
Yan Z, Ohuchida K, Fei S, Zheng B, Guan W, Feng H, Kibe S, Ando Y, Koikawa K, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Hashizume M, Nakamura M. Yan Z, et al. Among authors: iwamoto c. J Exp Clin Cancer Res. 2019 May 27;38(1):221. doi: 10.1186/s13046-019-1226-8. J Exp Clin Cancer Res. 2019. PMID: 31133044 Free PMC article.
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
Endo S, Nakata K, Ohuchida K, Takesue S, Nakayama H, Abe T, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Endo S, et al. Among authors: iwamoto c. Gastroenterology. 2017 May;152(6):1492-1506.e24. doi: 10.1053/j.gastro.2017.01.010. Epub 2017 Jan 23. Gastroenterology. 2017. PMID: 28126348
Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.
Okumura T, Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Okumura T, et al. Among authors: iwamoto c. Oncotarget. 2017 Mar 14;8(11):18280-18295. doi: 10.18632/oncotarget.15430. Oncotarget. 2017. PMID: 28407685 Free PMC article.
Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.
Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Koikawa K, et al. Among authors: iwamoto c. Cancer Lett. 2018 Jan 1;412:143-154. doi: 10.1016/j.canlet.2017.10.010. Epub 2017 Oct 20. Cancer Lett. 2018. PMID: 29061505
Basement membrane destruction by pancreatic stellate cells leads to local invasion in pancreatic ductal adenocarcinoma.
Koikawa K, Ohuchida K, Ando Y, Kibe S, Nakayama H, Takesue S, Endo S, Abe T, Okumura T, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M. Koikawa K, et al. Among authors: iwamoto c. Cancer Lett. 2018 Jul 1;425:65-77. doi: 10.1016/j.canlet.2018.03.031. Epub 2018 Mar 23. Cancer Lett. 2018. PMID: 29580808
Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix.
Okumura T, Ohuchida K, Kibe S, Iwamoto C, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Sada M, Horioka K, Mochidome N, Arita M, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Okumura T, et al. Among authors: iwamoto c. Int J Cancer. 2019 Mar 15;144(6):1401-1413. doi: 10.1002/ijc.31775. Epub 2018 Oct 10. Int J Cancer. 2019. PMID: 30152542 Free article.
Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion.
Kibe S, Ohuchida K, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Okumura T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Shimamoto M, Ohtsuka T, Mizumoto K, Oda Y, Nakamura M. Kibe S, et al. Among authors: iwamoto c. Cancer Lett. 2019 Mar 1;444:70-81. doi: 10.1016/j.canlet.2018.12.005. Epub 2018 Dec 24. Cancer Lett. 2019. PMID: 30590101 Free article.
CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.
Yan Z, Ohuchida K, Zheng B, Okumura T, Takesue S, Nakayama H, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M. Yan Z, et al. Among authors: iwamoto c. J Cancer Res Clin Oncol. 2019 May;145(5):1147-1164. doi: 10.1007/s00432-019-02860-z. Epub 2019 Feb 15. J Cancer Res Clin Oncol. 2019. PMID: 30770989
94 results