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Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model.
Fushimura Y, Hoshino A, Furukawa S, Nakagawa T, Hino T, Taminishi S, Minami Y, Urata R, Iwai-Kanai E, Matoba S. Fushimura Y, et al. Among authors: iwai kanai e. Biochem Biophys Res Commun. 2021 Dec 31;585:191-195. doi: 10.1016/j.bbrc.2021.10.060. Epub 2021 Oct 29. Biochem Biophys Res Commun. 2021. PMID: 34813979
p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress.
Kimata M, Matoba S, Iwai-Kanai E, Nakamura H, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Mita Y, Okigaki M, Ikeda K, Tatsumi T, Matsubara H. Kimata M, et al. Am J Physiol Heart Circ Physiol. 2010 Dec;299(6):H1908-16. doi: 10.1152/ajpheart.00250.2010. Epub 2010 Oct 8. Am J Physiol Heart Circ Physiol. 2010. PMID: 20935145 Free article.
p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia.
Hoshino A, Matoba S, Iwai-Kanai E, Nakamura H, Kimata M, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Ueyama T, Okigaki M, Matsubara H. Hoshino A, et al. J Mol Cell Cardiol. 2012 Jan;52(1):175-84. doi: 10.1016/j.yjmcc.2011.10.008. Epub 2011 Oct 18. J Mol Cell Cardiol. 2012. PMID: 22044588
p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation.
Nakamura H, Matoba S, Iwai-Kanai E, Kimata M, Hoshino A, Nakaoka M, Katamura M, Okawa Y, Ariyoshi M, Mita Y, Ikeda K, Okigaki M, Adachi S, Tanaka H, Takamatsu T, Matsubara H. Nakamura H, et al. Circ Heart Fail. 2012 Jan;5(1):106-15. doi: 10.1161/CIRCHEARTFAILURE.111.961565. Epub 2011 Nov 9. Circ Heart Fail. 2012. PMID: 22075967
34 results