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Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders.
Wu X, Yang X, Xiong Y, Li R, Ito T, Ahmed TA, Karoulia Z, Adamopoulos C, Wang H, Wang L, Xie L, Liu J, Ueberheide B, Aaronson SA, Chen X, Buchanan SG, Sellers WR, Jin J, Poulikakos PI. Wu X, et al. Among authors: ito t. Nat Cancer. 2021 Apr;2(4):429-443. doi: 10.1038/s43018-021-00174-z. Epub 2021 Mar 1. Nat Cancer. 2021. PMID: 34568836 Free PMC article.
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.
Ito T, Young MJ, Li R, Jain S, Wernitznig A, Krill-Burger JM, Lemke CT, Monducci D, Rodriguez DJ, Chang L, Dutta S, Pal D, Paolella BR, Rothberg MV, Root DE, Johannessen CM, Parida L, Getz G, Vazquez F, Doench JG, Zamanighomi M, Sellers WR. Ito T, et al. Nat Genet. 2021 Dec;53(12):1664-1672. doi: 10.1038/s41588-021-00967-z. Epub 2021 Dec 2. Nat Genet. 2021. PMID: 34857952
Comparative optimization of combinatorial CRISPR screens.
Li R, Klingbeil O, Monducci D, Young MJ, Rodriguez DJ, Bayyat Z, Dempster JM, Kesar D, Yang X, Zamanighomi M, Vakoc CR, Ito T, Sellers WR. Li R, et al. Among authors: ito t. Nat Commun. 2022 May 5;13(1):2469. doi: 10.1038/s41467-022-30196-9. Nat Commun. 2022. PMID: 35513429 Free PMC article.
A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury.
Calafiore M, Fu YY, Vinci P, Arnhold V, Chang WY, Jansen SA, Egorova A, Takashima S, Kuttiyara J, Ito T, Serody J, Nakae S, Turnquist H, van Es J, Clevers H, Lindemans CA, Blazar BR, Hanash AM. Calafiore M, et al. Among authors: ito t. Nat Commun. 2023 Sep 5;14(1):5411. doi: 10.1038/s41467-023-40993-5. Nat Commun. 2023. PMID: 37669929 Free PMC article.
J-AVENUE: A retrospective, real-world study evaluating patient characteristics and outcomes in patients with advanced urothelial carcinoma treated with avelumab first-line maintenance therapy in Japan.
Kikuchi E, Hayakawa N, Nakayama M, Uno M, Nakatsu H, Kitagawa C, Miyake H, Yamada T, Fujita K, Shimoyama H, Nishihara K, Kobayashi M, Nakamura M, Fujimoto K, Sano T, Nishiyama N, Ito T, Kajita M, Kobayashi T, Kitamura H. Kikuchi E, et al. Among authors: ito t. Int J Urol. 2024 May 9. doi: 10.1111/iju.15473. Online ahead of print. Int J Urol. 2024. PMID: 38722221
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