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Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita.
Nachmani D, Bothmer AH, Grisendi S, Mele A, Bothmer D, Lee JD, Monteleone E, Cheng K, Zhang Y, Bester AC, Guzzetti A, Mitchell CA, Mendez LM, Pozdnyakova O, Sportoletti P, Martelli MP, Vulliamy TJ, Safra M, Schwartz S, Luzzatto L, Bluteau O, Soulier J, Darnell RB, Falini B, Dokal I, Ito K, Clohessy JG, Pandolfi PP. Nachmani D, et al. Among authors: ito k. Nat Genet. 2019 Oct;51(10):1518-1529. doi: 10.1038/s41588-019-0502-z. Epub 2019 Sep 30. Nat Genet. 2019. PMID: 31570891 Free PMC article.
PML targeting eradicates quiescent leukaemia-initiating cells.
Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, Rosenblatt J, Avigan DE, Teruya-Feldstein J, Pandolfi PP. Ito K, et al. Nature. 2008 Jun 19;453(7198):1072-8. doi: 10.1038/nature07016. Epub 2008 May 11. Nature. 2008. PMID: 18469801 Free PMC article.
The nuclear bodies inside out: PML conquers the cytoplasm.
Carracedo A, Ito K, Pandolfi PP. Carracedo A, et al. Among authors: ito k. Curr Opin Cell Biol. 2011 Jun;23(3):360-6. doi: 10.1016/j.ceb.2011.03.011. Epub 2011 Apr 16. Curr Opin Cell Biol. 2011. PMID: 21501958 Free PMC article. Review.
A metabolic prosurvival role for PML in breast cancer.
Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. Carracedo A, et al. Among authors: ito k. J Clin Invest. 2012 Sep;122(9):3088-100. doi: 10.1172/JCI62129. Epub 2012 Aug 13. J Clin Invest. 2012. PMID: 22886304 Free PMC article.
MUC1 is a potential target for the treatment of acute myeloid leukemia stem cells.
Stroopinsky D, Rosenblatt J, Ito K, Mills H, Yin L, Rajabi H, Vasir B, Kufe T, Luptakova K, Arnason J, Nardella C, Levine JD, Joyce RM, Galinsky I, Reiter Y, Stone RM, Pandolfi PP, Kufe D, Avigan D. Stroopinsky D, et al. Among authors: ito k. Cancer Res. 2013 Sep 1;73(17):5569-79. doi: 10.1158/0008-5472.CAN-13-0677. Epub 2013 Jul 18. Cancer Res. 2013. PMID: 23867470 Free PMC article.
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