Ismail NSM - Search Results

1

Development of pyrolo[2,3-c]pyrazole, pyrolo[2,3-d]pyrimidine and their bioisosteres as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological evaluation and molecular dynamics investigations.

Azmy EM, Hagras M, Ewida MA, Doghish AS, Gamil Khidr E, El-Husseiny AA, Gomaa MH, Refaat HM, Ismail NSM, Nassar IF, Lashin WH. Azmy EM, et al. Among authors: ismail nsm. Bioorg Chem. 2023 Oct;139:106729. doi: 10.1016/j.bioorg.2023.106729. Epub 2023 Jul 13. Bioorg Chem. 2023. PMID: 37467621

2

Computer based design, synthesis and biological evaluation of novel indole derivatives as HCV NS3-4A serine protease inhibitors.

Ismail NS, El Dine RS, Hattori M, Takahashi K, Ihara M. Ismail NS, et al. Bioorg Med Chem. 2008 Sep 1;16(17):7877-87. doi: 10.1016/j.bmc.2008.07.084. Epub 2008 Aug 3. Bioorg Med Chem. 2008. PMID: 18752958

3

ACE inhibitors hypothesis generation for selective design, synthesis and biological evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as antihypertensive agents.

Ismail MA, Nabil Aboul-Enein M, Abouzid KA, Abou El Ella DA, Ismail NS. Ismail MA, et al. Bioorg Med Chem. 2009 May 15;17(10):3739-46. doi: 10.1016/j.bmc.2009.03.008. Epub 2009 Mar 10. Bioorg Med Chem. 2009. PMID: 19403313

4

A convenient synthesis and molecular modeling study of novel purine and pyrimidine derivatives as CDK2/cyclin A3 inhibitors.

Elgazwy AS, Ismail NS, Elzahabi HS. Elgazwy AS, et al. Bioorg Med Chem. 2010 Nov 1;18(21):7639-50. doi: 10.1016/j.bmc.2010.08.033. Epub 2010 Aug 26. Bioorg Med Chem. 2010. PMID: 20851615

5

Molecular modeling based approach, synthesis and in vitro assay to new indole inhibitors of hepatitis C NS3/4A serine protease.

Ismail NS, Hattori M. Ismail NS, et al. Bioorg Med Chem. 2011 Jan 1;19(1):374-83. doi: 10.1016/j.bmc.2010.11.017. Epub 2010 Nov 11. Bioorg Med Chem. 2011. PMID: 21138791

6

Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity.

Lasheen DS, Ismail MA, Abou El Ella DA, Ismail NS, Eid S, Vleck S, Glenn JS, Watts AG, Abouzid KA. Lasheen DS, et al. Bioorg Med Chem. 2013 May 15;21(10):2742-55. doi: 10.1016/j.bmc.2013.03.017. Epub 2013 Mar 24. Bioorg Med Chem. 2013. PMID: 23583031

7

Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold.

Shahin MI, Abou El Ella DA, Ismail NS, Abouzid KA. Shahin MI, et al. Bioorg Chem. 2014 Oct;56:16-26. doi: 10.1016/j.bioorg.2014.05.010. Epub 2014 May 28. Bioorg Chem. 2014. PMID: 24922538

8

Design, synthesis and anticancer evaluation of novel pyrazole, pyrazolo[3,4-d]pyrimidine and their glycoside derivatives.

Nassar IF, El Farargy AF, Abdelrazek FM, Ismail NSM. Nassar IF, et al. Among authors: ismail nsm. Nucleosides Nucleotides Nucleic Acids. 2017 Apr 3;36(4):275-291. doi: 10.1080/15257770.2016.1276290. Epub 2017 Mar 21. Nucleosides Nucleotides Nucleic Acids. 2017. PMID: 28323527

9

Design, synthesis and molecular modeling study of certain VEGFR-2 inhibitors based on thienopyrimidne scaffold as cancer targeting agents.

Ghith A, Youssef KM, Ismail NSM, Abouzid KAM. Ghith A, et al. Among authors: ismail nsm. Bioorg Chem. 2019 Mar;83:111-128. doi: 10.1016/j.bioorg.2018.10.008. Epub 2018 Oct 10. Bioorg Chem. 2019. PMID: 30343204

10

Design, synthesis and biological evaluation of certain CDK2 inhibitors based on pyrazole and pyrazolo[1,5-a] pyrimidine scaffold with apoptotic activity.

Ali GME, Ibrahim DA, Elmetwali AM, Ismail NSM. Ali GME, et al. Among authors: ismail nsm. Bioorg Chem. 2019 May;86:1-14. doi: 10.1016/j.bioorg.2019.01.008. Epub 2019 Jan 17. Bioorg Chem. 2019. PMID: 30682722

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