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Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B.
King TI, Indapurkar A, Tariq I, DePalma R, Mistry S, Alvarez-Baron C, Ismaiel OA, Wu W, Chiu K, Patel V, Rouse R, Strauss DG, Matta MK. King TI, et al. Among authors: ismaiel oa. J Pharmacol Toxicol Methods. 2022 Nov-Dec;118:107229. doi: 10.1016/j.vascn.2022.107229. Epub 2022 Nov 9. J Pharmacol Toxicol Methods. 2022. PMID: 36334898 Free article.
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss.
Alvarez Baron C, Thiebaud N, Ren M, Viatchenko-Karpinski S, Indapurkar A, King T, Matta MK, Ismaiel OA, Patel V, Mashaee M, Vicente J, Wu WW. Alvarez Baron C, et al. Among authors: ismaiel oa. J Pharmacol Toxicol Methods. 2022 Sep-Oct;117:107193. doi: 10.1016/j.vascn.2022.107193. Epub 2022 Jul 2. J Pharmacol Toxicol Methods. 2022. PMID: 35792285 Free article.
Effect of Paroxetine or Quetiapine Combined With Oxycodone vs Oxycodone Alone on Ventilation During Hypercapnia: A Randomized Clinical Trial.
Florian J, van der Schrier R, Gershuny V, Davis MC, Wang C, Han X, Burkhart K, Prentice K, Shah A, Racz R, Patel V, Matta M, Ismaiel OA, Weaver J, Boughner R, Ford K, Rouse R, Stone M, Sanabria C, Dahan A, Strauss DG. Florian J, et al. Among authors: ismaiel oa. JAMA. 2022 Oct 11;328(14):1405-1414. doi: 10.1001/jama.2022.17735. JAMA. 2022. PMID: 36219407 Free PMC article. Clinical Trial.
New science, drug regulation, and emergent public health issues: The work of FDA's division of applied regulatory science.
Chiu K, Racz R, Burkhart K, Florian J, Ford K, Iveth Garcia M, Geiger RM, Howard KE, Hyland PL, Ismaiel OA, Kruhlak NL, Li Z, Matta MK, Prentice KW, Shah A, Stavitskaya L, Volpe DA, Weaver JL, Wu WW, Rouse R, Strauss DG. Chiu K, et al. Among authors: ismaiel oa. Front Med (Lausanne). 2023 Jan 19;9:1109541. doi: 10.3389/fmed.2022.1109541. eCollection 2022. Front Med (Lausanne). 2023. PMID: 36743666 Free PMC article. Review.
Multiplex Hybrid Antigen-Capture LC-MRM Quantification in Sera and Nasal Lining Fluid of AZD7442, a SARS-CoV-2-Targeting Antibody Combination.
Mu R, Huang Y, Bouquet J, Yuan J, Kubiak RJ, Ma E, Naser S, Mylott WR Jr, Ismaiel OA, Wheeler AM, Burkart R, Cortes DF, Bruton J, Arends RH, Liang M, Rosenbaum AI. Mu R, et al. Among authors: ismaiel oa. Anal Chem. 2022 Nov 1;94(43):14835-14845. doi: 10.1021/acs.analchem.2c01320. Epub 2022 Oct 21. Anal Chem. 2022. PMID: 36269894 Free PMC article.
Comparison of methods for quantitative analysis of ranibizumab and bevacizumab in human plasma using various bioanalytical techniques, including microfluidic immunoassay, triple quadrupole, and high-resolution liquid chromatography-tandem mass spectrometry approaches.
DelGuidice CE, Ismaiel OA, Mylott WR Jr, Halquist MS. DelGuidice CE, et al. Among authors: ismaiel oa. J Pharm Biomed Anal. 2022 Aug 5;217:114823. doi: 10.1016/j.jpba.2022.114823. Epub 2022 May 10. J Pharm Biomed Anal. 2022. PMID: 35576733
Optimization and method validation for the quantitative analysis of a monoclonal antibody and its related fab fragment in human plasma after intravitreal administration, using LC-MS/MS.
DelGuidice CE, Ismaiel OA, Mylott WR Jr, Halquist MS. DelGuidice CE, et al. Among authors: ismaiel oa. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Feb 1;1164:122474. doi: 10.1016/j.jchromb.2020.122474. Epub 2021 Jan 9. J Chromatogr B Analyt Technol Biomed Life Sci. 2021. PMID: 33508760
23 results