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IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression.
Sadik A, Somarribas Patterson LF, Öztürk S, Mohapatra SR, Panitz V, Secker PF, Pfänder P, Loth S, Salem H, Prentzell MT, Berdel B, Iskar M, Faessler E, Reuter F, Kirst I, Kalter V, Foerster KI, Jäger E, Guevara CR, Sobeh M, Hielscher T, Poschet G, Reinhardt A, Hassel JC, Zapatka M, Hahn U, von Deimling A, Hopf C, Schlichting R, Escher BI, Burhenne J, Haefeli WE, Ishaque N, Böhme A, Schäuble S, Thedieck K, Trump S, Seiffert M, Opitz CA. Sadik A, et al. Among authors: iskar m. Cell. 2020 Sep 3;182(5):1252-1270.e34. doi: 10.1016/j.cell.2020.07.038. Epub 2020 Aug 19. Cell. 2020. PMID: 32818467 Free article.
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity.
Hanna BS, Llaó-Cid L, Iskar M, Roessner PM, Klett LC, Wong JKL, Paul Y, Ioannou N, Öztürk S, Mack N, Kalter V, Colomer D, Campo E, Bloehdorn J, Stilgenbauer S, Dietrich S, Schmidt M, Gabriel R, Rippe K, Feuerer M, Ramsay AG, Lichter P, Zapatka M, Seiffert M. Hanna BS, et al. Among authors: iskar m. Immunity. 2021 Dec 14;54(12):2825-2841.e10. doi: 10.1016/j.immuni.2021.11.004. Epub 2021 Dec 7. Immunity. 2021. PMID: 34879221 Free article.
Tumor-derived exosomes modulate PD-L1 expression in monocytes.
Haderk F, Schulz R, Iskar M, Cid LL, Worst T, Willmund KV, Schulz A, Warnken U, Seiler J, Benner A, Nessling M, Zenz T, Göbel M, Dürig J, Diederichs S, Paggetti J, Moussay E, Stilgenbauer S, Zapatka M, Lichter P, Seiffert M. Haderk F, et al. Among authors: iskar m. Sci Immunol. 2017 Jul 28;2(13):eaah5509. doi: 10.1126/sciimmunol.aah5509. Sci Immunol. 2017. PMID: 28754746
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks.
Mallm JP, Iskar M, Ishaque N, Klett LC, Kugler SJ, Muino JM, Teif VB, Poos AM, Großmann S, Erdel F, Tavernari D, Koser SD, Schumacher S, Brors B, König R, Remondini D, Vingron M, Stilgenbauer S, Lichter P, Zapatka M, Mertens D, Rippe K. Mallm JP, et al. Among authors: iskar m. Mol Syst Biol. 2019 May 22;15(5):e8339. doi: 10.15252/msb.20188339. Mol Syst Biol. 2019. PMID: 31118277 Free PMC article.
Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.
Chun HE, Johann PD, Milne K, Zapatka M, Buellesbach A, Ishaque N, Iskar M, Erkek S, Wei L, Tessier-Cloutier B, Lever J, Titmuss E, Topham JT, Bowlby R, Chuah E, Mungall KL, Ma Y, Mungall AJ, Moore RA, Taylor MD, Gerhard DS, Jones SJM, Korshunov A, Gessler M, Kerl K, Hasselblatt M, Frühwald MC, Perlman EJ, Nelson BH, Pfister SM, Marra MA, Kool M. Chun HE, et al. Among authors: iskar m. Cell Rep. 2019 Nov 19;29(8):2338-2354.e7. doi: 10.1016/j.celrep.2019.10.013. Epub 2019 Nov 7. Cell Rep. 2019. PMID: 31708418 Free PMC article.
Molecular subgrouping of primary pineal parenchymal tumors reveals distinct subtypes correlated with clinical parameters and genetic alterations.
Pfaff E, Aichmüller C, Sill M, Stichel D, Snuderl M, Karajannis MA, Schuhmann MU, Schittenhelm J, Hasselblatt M, Thomas C, Korshunov A, Rhizova M, Wittmann A, Kaufhold A, Iskar M, Ketteler P, Lohmann D, Orr BA, Ellison DW, von Hoff K, Mynarek M, Rutkowski S, Sahm F, von Deimling A, Lichter P, Kool M, Zapatka M, Pfister SM, Jones DTW. Pfaff E, et al. Among authors: iskar m. Acta Neuropathol. 2020 Feb;139(2):243-257. doi: 10.1007/s00401-019-02101-0. Epub 2019 Nov 25. Acta Neuropathol. 2020. PMID: 31768671 Free PMC article.
A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis.
Khalid U, Simovic M, Hammann LA, Iskar M, Wong JKL, Kumar R, Jugold M, Sill M, Bolkestein M, Kolb T, Hergt M, Devens F, Ecker J, Kool M, Milde T, Westermann F, Benner A, Lewis J, Dietrich S, Pfister SM, Lichter P, Zapatka M, Ernst A. Khalid U, et al. Among authors: iskar m. Int J Cancer. 2022 Aug 15;151(4):590-606. doi: 10.1002/ijc.34027. Epub 2022 Apr 28. Int J Cancer. 2022. PMID: 35411591 Free article.
76 results