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Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans.
Hikida T, Jaaro-Peled H, Seshadri S, Oishi K, Hookway C, Kong S, Wu D, Xue R, Andradé M, Tankou S, Mori S, Gallagher M, Ishizuka K, Pletnikov M, Kida S, Sawa A. Hikida T, et al. Among authors: ishizuka k. Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14501-6. doi: 10.1073/pnas.0704774104. Epub 2007 Aug 3. Proc Natl Acad Sci U S A. 2007. PMID: 17675407 Free PMC article.
Evidence that many of the DISC1 isoforms in C57BL/6J mice are also expressed in 129S6/SvEv mice.
Ishizuka K, Chen J, Taya S, Li W, Millar JK, Xu Y, Clapcote SJ, Hookway C, Morita M, Kamiya A, Tomoda T, Lipska BK, Roder JC, Pletnikov M, Porteous D, Silva AJ, Cannon TD, Kaibuchi K, Brandon NJ, Weinberger DR, Sawa A. Ishizuka K, et al. Mol Psychiatry. 2007 Oct;12(10):897-9. doi: 10.1038/sj.mp.4002024. Mol Psychiatry. 2007. PMID: 17895924 No abstract available.
Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.
Sawamura N, Ando T, Maruyama Y, Fujimuro M, Mochizuki H, Honjo K, Shimoda M, Toda H, Sawamura-Yamamoto T, Makuch LA, Hayashi A, Ishizuka K, Cascella NG, Kamiya A, Ishida N, Tomoda T, Hai T, Furukubo-Tokunaga K, Sawa A. Sawamura N, et al. Among authors: ishizuka k. Mol Psychiatry. 2008 Dec;13(12):1138-48, 1069. doi: 10.1038/mp.2008.101. Epub 2008 Sep 2. Mol Psychiatry. 2008. PMID: 18762802 Free PMC article.
Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1.
Hayashi-Takagi A, Takaki M, Graziane N, Seshadri S, Murdoch H, Dunlop AJ, Makino Y, Seshadri AJ, Ishizuka K, Srivastava DP, Xie Z, Baraban JM, Houslay MD, Tomoda T, Brandon NJ, Kamiya A, Yan Z, Penzes P, Sawa A. Hayashi-Takagi A, et al. Among authors: ishizuka k. Nat Neurosci. 2010 Mar;13(3):327-32. doi: 10.1038/nn.2487. Epub 2010 Feb 7. Nat Neurosci. 2010. PMID: 20139976 Free PMC article.
522 results