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Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells.
Nakano K, Orita T, Nezu J, Yoshino T, Ohizumi I, Sugimoto M, Furugaki K, Kinoshita Y, Ishiguro T, Hamakubo T, Kodama T, Aburatani H, Yamada-Okabe H, Tsuchiya M. Nakano K, et al. Among authors: ishiguro t. Biochem Biophys Res Commun. 2009 Jan 9;378(2):279-84. doi: 10.1016/j.bbrc.2008.11.033. Epub 2008 Nov 18. Biochem Biophys Res Commun. 2009. PMID: 19022220
2D7 diabody bound to the alpha2 domain of HLA class I efficiently induces caspase-independent cell death against malignant and activated lymphoid cells.
Kimura N, Kawai S, Kinoshita Y, Ishiguro T, Azuma Y, Ozaki S, Abe M, Sugimoto M, Hirata Y, Orita T, Okabe H, Matsumoto T, Tsuchiya M. Kimura N, et al. Among authors: ishiguro t. Biochem Biophys Res Commun. 2004 Dec 24;325(4):1201-9. doi: 10.1016/j.bbrc.2004.10.163. Biochem Biophys Res Commun. 2004. PMID: 15555554
An anti-glypican 3/CD3 bispecific T cell-redirecting antibody for treatment of solid tumors.
Ishiguro T, Sano Y, Komatsu SI, Kamata-Sakurai M, Kaneko A, Kinoshita Y, Shiraiwa H, Azuma Y, Tsunenari T, Kayukawa Y, Sonobe Y, Ono N, Sakata K, Fujii T, Miyazaki Y, Noguchi M, Endo M, Harada A, Frings W, Fujii E, Nanba E, Narita A, Sakamoto A, Wakabayashi T, Konishi H, Segawa H, Igawa T, Tsushima T, Mutoh H, Nishito Y, Takahashi M, Stewart L, ElGabry E, Kawabe Y, Ishigai M, Chiba S, Aoki M, Hattori K, Nezu J. Ishiguro T, et al. Sci Transl Med. 2017 Oct 4;9(410):eaal4291. doi: 10.1126/scitranslmed.aal4291. Sci Transl Med. 2017. PMID: 28978751
Entire CD3ε, δ, and γ humanized mouse to evaluate human CD3-mediated therapeutics.
Ueda O, Wada NA, Kinoshita Y, Hino H, Kakefuda M, Ito T, Fujii E, Noguchi M, Sato K, Morita M, Tateishi H, Matsumoto K, Goto C, Kawase Y, Kato A, Hattori K, Nezu J, Ishiguro T, Jishage KI. Ueda O, et al. Among authors: ishiguro t. Sci Rep. 2017 Apr 3;7:45839. doi: 10.1038/srep45839. Sci Rep. 2017. PMID: 28368009 Free PMC article.
Combination of T cell-redirecting bispecific antibody ERY974 and chemotherapy reciprocally enhances efficacy against non-inflamed tumours.
Sano Y, Azuma Y, Tsunenari T, Kayukawa Y, Shinozuka J, Fujii E, Amano J, Nishito Y, Maruyama T, Kinoshita Y, Sakamoto Y, Yoshida A, Miyazaki Y, Sato Y, Teramoto-Seida C, Ishiguro T, Tanaka T, Kitazawa T, Endo M. Sano Y, et al. Among authors: ishiguro t. Nat Commun. 2022 Sep 7;13(1):5265. doi: 10.1038/s41467-022-32952-3. Nat Commun. 2022. PMID: 36071036 Free PMC article.
935 results