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PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models.
Nat Commun. 2023 Sep 26;14(1):5983. doi: 10.1038/s41467-023-41737-1.
Nat Commun. 2023.
PMID: 37752135
Free PMC article.
The iron-regulated vacuolar Legionella pneumophila MavN protein is a transition-metal transporter.
Christenson ET, Isaac DT, Yoshida K, Lipo E, Kim JS, Ghirlando R, Isberg RR, Banerjee A.
Christenson ET, et al. Among authors: isaac dt.
Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17775-17785. doi: 10.1073/pnas.1902806116. Epub 2019 Aug 20.
Proc Natl Acad Sci U S A. 2019.
PMID: 31431530
Free PMC article.
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MavN is a Legionella pneumophila vacuole-associated protein required for efficient iron acquisition during intracellular growth.
Isaac DT, Laguna RK, Valtz N, Isberg RR.
Isaac DT, et al.
Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):E5208-17. doi: 10.1073/pnas.1511389112. Epub 2015 Sep 1.
Proc Natl Acad Sci U S A. 2015.
PMID: 26330609
Free PMC article.
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Macrophage cell death and transcriptional response are actively triggered by the fungal virulence factor Cbp1 during H. capsulatum infection.
Isaac DT, Berkes CA, English BC, Murray DH, Lee YN, Coady A, Sil A.
Isaac DT, et al.
Mol Microbiol. 2015 Dec;98(5):910-929. doi: 10.1111/mmi.13168. Epub 2015 Sep 29.
Mol Microbiol. 2015.
PMID: 26288377
Free PMC article.
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Master manipulators: an update on Legionella pneumophila Icm/Dot translocated substrates and their host targets.
Isaac DT, Isberg R.
Isaac DT, et al.
Future Microbiol. 2014;9(3):343-59. doi: 10.2217/fmb.13.162.
Future Microbiol. 2014.
PMID: 24762308
Free PMC article.
Review.
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The 3-hydroxy-methylglutaryl coenzyme A lyase HCL1 is required for macrophage colonization by human fungal pathogen Histoplasma capsulatum.
Isaac DT, Coady A, Van Prooyen N, Sil A.
Isaac DT, et al.
Infect Immun. 2013 Feb;81(2):411-20. doi: 10.1128/IAI.00833-12. Epub 2012 Nov 26.
Infect Immun. 2013.
PMID: 23184522
Free PMC article.
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