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Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function.
Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella IL, Bogaards SJP, Conijn SP, Ottenheijm CAC, Hwang HS, Papadaki M, Knollmann BC, Sadayappan S, Irving TC, Galkin VE, Chase PB, Pinto JR. Landim-Vieira M, et al. Among authors: irving tc. Proc Natl Acad Sci U S A. 2023 Jun 6;120(23):e2221244120. doi: 10.1073/pnas.2221244120. Epub 2023 May 30. Proc Natl Acad Sci U S A. 2023. PMID: 37252999 Free PMC article.
Reverse actin sliding triggers strong myosin binding that moves tropomyosin.
Bekyarova TI, Reedy MC, Baumann BA, Tregear RT, Ward A, Krzic U, Prince KM, Perz-Edwards RJ, Reconditi M, Gore D, Irving TC, Reedy MK. Bekyarova TI, et al. Among authors: irving tc. Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10372-7. doi: 10.1073/pnas.0709877105. Epub 2008 Jul 25. Proc Natl Acad Sci U S A. 2008. PMID: 18658238 Free PMC article.
Myofilament length dependent activation.
de Tombe PP, Mateja RD, Tachampa K, Ait Mou Y, Farman GP, Irving TC. de Tombe PP, et al. Among authors: irving tc. J Mol Cell Cardiol. 2010 May;48(5):851-8. doi: 10.1016/j.yjmcc.2009.12.017. Epub 2010 Jan 4. J Mol Cell Cardiol. 2010. PMID: 20053351 Free PMC article. Review.
Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome.
Ottenheijm CA, Voermans NC, Hudson BD, Irving T, Stienen GJ, van Engelen BG, Granzier H. Ottenheijm CA, et al. J Appl Physiol (1985). 2012 Apr;112(7):1157-65. doi: 10.1152/japplphysiol.01166.2011. Epub 2012 Jan 5. J Appl Physiol (1985). 2012. PMID: 22223454 Free PMC article.
Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium.
Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S. Witayavanitkul N, et al. J Biol Chem. 2014 Mar 28;289(13):8818-27. doi: 10.1074/jbc.M113.541128. Epub 2014 Feb 7. J Biol Chem. 2014. PMID: 24509847 Free PMC article.
167 results