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Design and Efficacy of a Monovalent Bispecific PD-1/CTLA4 Antibody That Enhances CTLA4 Blockade on PD-1+ Activated T Cells.
Dovedi SJ, Elder MJ, Yang C, Sitnikova SI, Irving L, Hansen A, Hair J, Jones DC, Hasani S, Wang B, Im SA, Tran B, Subramaniam DS, Gainer SD, Vashisht K, Lewis A, Jin X, Kentner S, Mulgrew K, Wang Y, Overstreet MG, Dodgson J, Wu Y, Palazon A, Morrow M, Rainey GJ, Browne GJ, Neal F, Murray TV, Toloczko AD, Dall'Acqua W, Achour I, Freeman DJ, Wilkinson RW, Mazor Y. Dovedi SJ, et al. Among authors: irving l. Cancer Discov. 2021 May;11(5):1100-1117. doi: 10.1158/2159-8290.CD-20-1445. Epub 2021 Jan 8. Cancer Discov. 2021. PMID: 33419761
Mechanistic insights into the rational design of masked antibodies.
Orozco CT, Bersellini M, Irving LM, Howard WW, Hargreaves D, Devine PWA, Siouve E, Browne GJ, Bond NJ, Phillips JJ, Ravn P, Jackson SE. Orozco CT, et al. MAbs. 2022 Jan-Dec;14(1):2095701. doi: 10.1080/19420862.2022.2095701. MAbs. 2022. PMID: 35799328 Free PMC article.
Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo.
Schofield DJ, Irving L, Calo L, Bogstedt A, Rees G, Nuccitelli A, Narwal R, Petrone M, Roberts J, Brown L, Cusdin F, Dosanjh B, Lloyd C, Dobson C, Gurrell I, Fraser G, McFarlane M, Rockenstein E, Spencer B, Masliah E, Spillantini MG, Tan K, Billinton A, Vaughan T, Chessell I, Perkinton MS. Schofield DJ, et al. Among authors: irving l. Neurobiol Dis. 2019 Dec;132:104582. doi: 10.1016/j.nbd.2019.104582. Epub 2019 Aug 21. Neurobiol Dis. 2019. PMID: 31445162 Free article.
Monoclonal antibody targeting of fibroblast growth factor receptor 1c ameliorates obesity and glucose intolerance via central mechanisms.
Lelliott CJ, Ahnmark A, Admyre T, Ahlstedt I, Irving L, Keyes F, Patterson L, Mumphrey MB, Bjursell M, Gorman T, Bohlooly-Y M, Buchanan A, Harrison P, Vaughan T, Berthoud HR, Lindén D. Lelliott CJ, et al. Among authors: irving l. PLoS One. 2014 Nov 26;9(11):e112109. doi: 10.1371/journal.pone.0112109. eCollection 2014. PLoS One. 2014. PMID: 25427253 Free PMC article.
IL-22 Binding Protein Promotes the Disease Process in Multiple Sclerosis.
Lindahl H, Guerreiro-Cacais AO, Bedri SK, Linnerbauer M, Lindén M, Abdelmagid N, Tandre K, Hollins C, Irving L, Glover C, Jones C, Alfredsson L, Rönnblom L, Kockum I, Khademi M, Jagodic M, Olsson T. Lindahl H, et al. Among authors: irving l. J Immunol. 2019 Aug 15;203(4):888-898. doi: 10.4049/jimmunol.1900400. Epub 2019 Jul 10. J Immunol. 2019. PMID: 31292217
Systematic endoscopic staging of mediastinum to guide radiotherapy planning in patients with locally advanced non-small-cell lung cancer (SEISMIC): an international, multicentre, single-arm, clinical trial.
Steinfort DP, Kothari G, Wallace N, Hardcastle N, Rangamuwa K, Dieleman EMT, Lee P, Li P, Simpson JA, Yo S, Bashirdazeh F, Nguyen P, Jennings BR, Fielding D, Crombag L, Irving LB, Yasufuku K, Annema JT, Ost DE, Siva S. Steinfort DP, et al. Among authors: irving lb. Lancet Respir Med. 2024 Mar 11:S2213-2600(24)00010-9. doi: 10.1016/S2213-2600(24)00010-9. Online ahead of print. Lancet Respir Med. 2024. PMID: 38490228
Validation of the psychosocial consequences of screening in lung cancer questionnaire in the international lung screen trial Australian cohort.
Bonney A, Brodersen J, Siersma V, See K, Marshall HM, Steinfort D, Irving L, Lin L, Li J, Pang S, Fogarty P, Brims F, McWilliams A, Stone E, Lam S, Fong KM, Manser R. Bonney A, et al. Among authors: irving l. Health Qual Life Outcomes. 2024 Jan 25;22(1):10. doi: 10.1186/s12955-023-02225-8. Health Qual Life Outcomes. 2024. PMID: 38273370 Free PMC article. Clinical Trial.
392 results