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The future of engineered immune cell therapies.
Irvine DJ, Maus MV, Mooney DJ, Wong WW. Irvine DJ, et al. Science. 2022 Nov 25;378(6622):853-858. doi: 10.1126/science.abq6990. Epub 2022 Nov 24. Science. 2022. PMID: 36423279 Free PMC article. Review.
Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters.
Dalvie NC, Rodriguez-Aponte SA, Hartwell BL, Tostanoski LH, Biedermann AM, Crowell LE, Kaur K, Kumru O, Carter L, Yu J, Chang A, McMahan K, Courant T, Lebas C, Lemnios AA, Rodrigues KA, Silva M, Johnston RS, Naranjo CA, Tracey MK, Brady JR, Whittaker CA, Yun D, Kar S, Porto M, Lok M, Andersen H, Lewis MG, Love KR, Camp DL, Silverman JM, Kleanthous H, Joshi SB, Volkin DB, Dubois PM, Collin N, King NP, Barouch DH, Irvine DJ, Love JC. Dalvie NC, et al. Among authors: irvine dj. bioRxiv [Preprint]. 2021 Mar 4:2021.03.03.433558. doi: 10.1101/2021.03.03.433558. bioRxiv. 2021. PMID: 33688647 Free PMC article. Updated. Preprint.
Delivering safer immunotherapies for cancer.
Milling L, Zhang Y, Irvine DJ. Milling L, et al. Among authors: irvine dj. Adv Drug Deliv Rev. 2017 May 15;114:79-101. doi: 10.1016/j.addr.2017.05.011. Epub 2017 May 22. Adv Drug Deliv Rev. 2017. PMID: 28545888 Free PMC article. Review.
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers.
Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ. Tokatlian T, et al. Among authors: irvine dj. Science. 2019 Feb 8;363(6427):649-654. doi: 10.1126/science.aat9120. Epub 2018 Dec 20. Science. 2019. PMID: 30573546 Free PMC article.
Enhancing cancer immunotherapy with nanomedicine.
Irvine DJ, Dane EL. Irvine DJ, et al. Nat Rev Immunol. 2020 May;20(5):321-334. doi: 10.1038/s41577-019-0269-6. Epub 2020 Jan 31. Nat Rev Immunol. 2020. PMID: 32005979 Free PMC article. Review.
Low protease activity in B cell follicles promotes retention of intact antigens after immunization.
Aung A, Cui A, Maiorino L, Amini AP, Gregory JR, Bukenya M, Zhang Y, Lee H, Cottrell CA, Morgan DM, Silva M, Suh H, Kirkpatrick JD, Amlashi P, Remba T, Froehle LM, Xiao S, Abraham W, Adams J, Love JC, Huyett P, Kwon DS, Hacohen N, Schief WR, Bhatia SN, Irvine DJ. Aung A, et al. Among authors: irvine dj. Science. 2023 Jan 27;379(6630):eabn8934. doi: 10.1126/science.abn8934. Epub 2023 Jan 27. Science. 2023. PMID: 36701450 Free PMC article.
Human STING is a proton channel.
Liu B, Carlson RJ, Pires IS, Gentili M, Feng E, Hellier Q, Schwartz MA, Blainey PC, Irvine DJ, Hacohen N. Liu B, et al. Among authors: irvine dj. Science. 2023 Aug 4;381(6657):508-514. doi: 10.1126/science.adf8974. Epub 2023 Aug 3. Science. 2023. PMID: 37535724
307 results