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The β-Secretase BACE1 in Alzheimer's Disease.
Hampel H, Vassar R, De Strooper B, Hardy J, Willem M, Singh N, Zhou J, Yan R, Vanmechelen E, De Vos A, Nisticò R, Corbo M, Imbimbo BP, Streffer J, Voytyuk I, Timmers M, Tahami Monfared AA, Irizarry M, Albala B, Koyama A, Watanabe N, Kimura T, Yarenis L, Lista S, Kramer L, Vergallo A. Hampel H, et al. Among authors: irizarry m. Biol Psychiatry. 2021 Apr 15;89(8):745-756. doi: 10.1016/j.biopsych.2020.02.001. Epub 2020 Feb 13. Biol Psychiatry. 2021. PMID: 32223911 Free PMC article. Review.
The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.
von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, Spoelgen R, Hshieh TT, Ranganathan S, Battey FD, Liu CX, Bacskai BJ, Sever S, Irizarry MC, Strickland DK, Hyman BT. von Arnim CA, et al. Among authors: irizarry mc. J Biol Chem. 2005 May 6;280(18):17777-85. doi: 10.1074/jbc.M414248200. Epub 2005 Mar 4. J Biol Chem. 2005. PMID: 15749709 Free article.
The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease.
Rafii MS, Sperling RA, Donohue MC, Zhou J, Roberts C, Irizarry MC, Dhadda S, Sethuraman G, Kramer LD, Swanson CJ, Li D, Krause S, Rissman RA, Walter S, Raman R, Johnson KA, Aisen PS. Rafii MS, et al. Alzheimers Dement. 2023 Apr;19(4):1227-1233. doi: 10.1002/alz.12748. Epub 2022 Aug 15. Alzheimers Dement. 2023. PMID: 35971310 Free PMC article.
Effects of simvastatin on cholesterol metabolism and Alzheimer disease biomarkers.
Serrano-Pozo A, Vega GL, Lütjohann D, Locascio JJ, Tennis MK, Deng A, Atri A, Hyman BT, Irizarry MC, Growdon JH. Serrano-Pozo A, et al. Alzheimer Dis Assoc Disord. 2010 Jul-Sep;24(3):220-6. doi: 10.1097/WAD.0b013e3181d61fea. Alzheimer Dis Assoc Disord. 2010. PMID: 20473136 Free PMC article. Clinical Trial.
Alzheimer disease therapeutics.
Irizarry MC, Hyman BT. Irizarry MC, et al. J Neuropathol Exp Neurol. 2001 Oct;60(10):923-8. doi: 10.1093/jnen/60.10.923. J Neuropathol Exp Neurol. 2001. PMID: 11589422 Review.
141 results