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Protocol and statistical analysis plan for the mega randomised registry trial research program comparing conservative versus liberal oxygenation targets in adults receiving unplanned invasive mechanical ventilation in the ICU (Mega-ROX).
Young PJ, Arabi YM, Bagshaw SM, Bellomo R, Fujii T, Haniffa R, Hodgson CL, Vijayaraghavan BKT, Litton E, Mackle D, Nichol AD, Kasza J; Mega-ROX Management Committee; Australian and New Zealand Intensive Care Society Clinical Trials Group; Crit Care Asia and Africa Network; Irish Critical Care Clinical Trials Group; Alberta Health Services Critical Care Strategic Clinical Network. Young PJ, et al. Crit Care Resusc. 2023 Oct 19;24(2):137-149. doi: 10.51893/2022.2.OA4. eCollection 2022 Jun 6. Crit Care Resusc. 2023. PMID: 38045600 Free PMC article.
Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains).
Young PJ, Al-Fares A, Aryal D, Arabi YM, Ashraf MS, Bagshaw SM, Mat-Nor MB, Beane A, Borghi G, de Oliveira Manoel AL, Dullawe L, Fazla F, Fujii T, Haniffa R, Hodgson CL, Hunt A, Lawrence C, Mackle D, Mangal K, Nichol AD, Olatunji S, Rashan A, Rashan S, Tomazini B, Kasza J; Mega-ROX management committee; Australian and New Zealand Intensive Care Society Clinical Trials Group; Brazilian Research in Intensive Care Network; Critical Care Asia and Africa Network; Irish Critical Care-Clinical Trials Group. Young PJ, et al. Crit Care Resusc. 2023 May 20;25(1):53-59. doi: 10.1016/j.ccrj.2023.04.011. eCollection 2023 Mar. Crit Care Resusc. 2023. PMID: 37876994 Free PMC article.
Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with sepsis in the intensive care unit (Mega-ROX Sepsis).
Young PJ, Al-Fares A, Aryal D, Arabi YM, Ashraf MS, Bagshaw SM, Beane A, de Oliveira Manoel AL, Dullawe L, Fazla F, Fujii T, Haniffa R, Hodgson CL, Hunt A, Tirupakuzhi Vijayaraghavan BK, Landoni G, Lawrence C, Maia IS, Mackle D, Mazlan MZ, Nichol AD, Olatunji S, Rashan A, Rashan S, Kasza J; Mega-ROX management committee; Australian and New Zealand Intensive Care Society Clinical Trials Group; Critical Care Asia and Africa Network; Irish Critical Care-Clinical Trials Group. Young PJ, et al. Crit Care Resusc. 2023 May 22;25(2):106-112. doi: 10.1016/j.ccrj.2023.04.008. eCollection 2023 Jun. Crit Care Resusc. 2023. PMID: 37876605 Free PMC article.