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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Henderson NC, et al. Among authors: iredale jp. Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10. Nat Med. 2013. PMID: 24216753 Free PMC article.
Modeling liver fibrosis in rodents.
Constandinou C, Henderson N, Iredale JP. Constandinou C, et al. Among authors: iredale jp. Methods Mol Med. 2005;117:237-50. doi: 10.1385/1-59259-940-0:237. Methods Mol Med. 2005. PMID: 16118456
Galectin-3 regulates myofibroblast activation and hepatic fibrosis.
Henderson NC, Mackinnon AC, Farnworth SL, Poirier F, Russo FP, Iredale JP, Haslett C, Simpson KJ, Sethi T. Henderson NC, et al. Among authors: iredale jp. Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5060-5. doi: 10.1073/pnas.0511167103. Epub 2006 Mar 20. Proc Natl Acad Sci U S A. 2006. PMID: 16549783 Free PMC article.
Origins of fibrosis: pericytes take centre stage.
Greenhalgh SN, Iredale JP, Henderson NC. Greenhalgh SN, et al. Among authors: iredale jp. F1000Prime Rep. 2013 Sep 2;5:37. doi: 10.12703/P5-37. F1000Prime Rep. 2013. PMID: 24049641 Free PMC article. Review.
Galectin-3 regulates hepatic progenitor cell expansion during liver injury.
Hsieh WC, Mackinnon AC, Lu WY, Jung J, Boulter L, Henderson NC, Simpson KJ, Schotanus B, Wojtacha D, Bird TG, Medine CN, Hay DC, Sethi T, Iredale JP, Forbes SJ. Hsieh WC, et al. Among authors: iredale jp. Gut. 2015 Feb;64(2):312-21. doi: 10.1136/gutjnl-2013-306290. Epub 2014 May 16. Gut. 2015. PMID: 24837171
11Beta-hydroxysteroid dehydrogenase-1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis.
Zou X, Ramachandran P, Kendall TJ, Pellicoro A, Dora E, Aucott RL, Manwani K, Man TY, Chapman KE, Henderson NC, Forbes SJ, Webster SP, Iredale JP, Walker BR, Michailidou Z. Zou X, et al. Among authors: iredale jp. Hepatology. 2018 Jun;67(6):2167-2181. doi: 10.1002/hep.29734. Epub 2018 Feb 22. Hepatology. 2018. PMID: 29251794 Free PMC article.
The STAT3-IL-10-IL-6 Pathway Is a Novel Regulator of Macrophage Efferocytosis and Phenotypic Conversion in Sterile Liver Injury.
Campana L, Starkey Lewis PJ, Pellicoro A, Aucott RL, Man J, O'Duibhir E, Mok SE, Ferreira-Gonzalez S, Livingstone E, Greenhalgh SN, Hull KL, Kendall TJ, Vernimmen D, Henderson NC, Boulter L, Gregory CD, Feng Y, Anderton SM, Forbes SJ, Iredale JP. Campana L, et al. Among authors: iredale jp. J Immunol. 2018 Feb 1;200(3):1169-1187. doi: 10.4049/jimmunol.1701247. Epub 2017 Dec 20. J Immunol. 2018. PMID: 29263216 Free PMC article.
180 results