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New biologic (Ab-IPL-IL-17) for IL-17-mediated diseases: identification of the bioactive sequence (nIL-17) for IL-17A/F function.
Saviano A, Manosour AA, Raucci F, Merlino F, Marigliano N, Schettino A, Wahid M, Begum J, Filer A, Manning JE, Casillo GM, Piccolo M, Ferraro MG, Marzano S, Russomanno P, Bellavita R, Irace C, Amato J, Alfaifi M, Rimmer P, Iqbal T, Pieretti S, Vellecco V, Caso F, Costa L, Giacomelli R, Scarpa R, Cirino G, Bucci M, McGettrick HM, Grieco P, Iqbal AJ, Maione F. Saviano A, et al. Among authors: irace c. Ann Rheum Dis. 2023 Nov;82(11):1415-1428. doi: 10.1136/ard-2023-224479. Epub 2023 Aug 14. Ann Rheum Dis. 2023. PMID: 37580108 Free PMC article.
Site-specific replacement of the thymine methyl group by fluorine in thrombin binding aptamer significantly improves structural stability and anticoagulant activity.
Virgilio A, Petraccone L, Vellecco V, Bucci M, Varra M, Irace C, Santamaria R, Pepe A, Mayol L, Esposito V, Galeone A. Virgilio A, et al. Among authors: irace c. Nucleic Acids Res. 2015 Dec 15;43(22):10602-11. doi: 10.1093/nar/gkv1224. Epub 2015 Nov 17. Nucleic Acids Res. 2015. PMID: 26582916 Free PMC article.
Down regulation of pro-inflammatory pathways by tanshinone IIA and cryptotanshinone in a non-genetic mouse model of Alzheimer's disease.
Maione F, Piccolo M, De Vita S, Chini MG, Cristiano C, De Caro C, Lippiello P, Miniaci MC, Santamaria R, Irace C, De Feo V, Calignano A, Mascolo N, Bifulco G. Maione F, et al. Among authors: irace c. Pharmacol Res. 2018 Mar;129:482-490. doi: 10.1016/j.phrs.2017.11.018. Epub 2017 Nov 20. Pharmacol Res. 2018. PMID: 29158049
Neutralization of IL-17 rescues amyloid-β-induced neuroinflammation and memory impairment.
Cristiano C, Volpicelli F, Lippiello P, Buono B, Raucci F, Piccolo M, Iqbal AJ, Irace C, Miniaci MC, Perrone Capano C, Calignano A, Mascolo N, Maione F. Cristiano C, et al. Among authors: irace c. Br J Pharmacol. 2019 Sep;176(18):3544-3557. doi: 10.1111/bph.14586. Epub 2019 Mar 3. Br J Pharmacol. 2019. PMID: 30673121 Free PMC article.
Exploring cellular uptake, accumulation and mechanism of action of a cationic Ru-based nanosystem in human preclinical models of breast cancer.
Piccolo M, Misso G, Ferraro MG, Riccardi C, Capuozzo A, Zarone MR, Maione F, Trifuoggi M, Stiuso P, D'Errico G, Caraglia M, Paduano L, Montesarchio D, Irace C, Santamaria R. Piccolo M, et al. Among authors: irace c. Sci Rep. 2019 May 7;9(1):7006. doi: 10.1038/s41598-019-43411-3. Sci Rep. 2019. PMID: 31065032 Free PMC article.
Bio-Inspired Dual-Selective BCL-2/c-MYC G-Quadruplex Binders: Design, Synthesis, and Anticancer Activity of Drug-like Imidazo[2,1-i]purine Derivatives.
Pelliccia S, Amato J, Capasso D, Di Gaetano S, Massarotti A, Piccolo M, Irace C, Tron GC, Pagano B, Randazzo A, Novellino E, Giustiniano M. Pelliccia S, et al. Among authors: irace c. J Med Chem. 2020 Mar 12;63(5):2035-2050. doi: 10.1021/acs.jmedchem.9b00262. Epub 2019 Jul 10. J Med Chem. 2020. PMID: 31241946
222 results