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A tetraprenylated benzophenone 7-epiclusianone induces cell cycle arrest at G1/S transition by modulating critical regulators of cell cycle in breast cancer cell lines.
Lamartine-Hanemann SDS, Ferreira-Silva GÁ, Horvath RO, Soncini R, Caixeta ES, Rocha-Sales B, Niero EL, Machado-Santelli GM, Dos Santos MH, de Oliveira JC, Miyazawa M, Ionta M. Lamartine-Hanemann SDS, et al. Among authors: ionta m. Toxicol In Vitro. 2020 Oct;68:104927. doi: 10.1016/j.tiv.2020.104927. Epub 2020 Jul 4. Toxicol In Vitro. 2020. PMID: 32634469 Free article.
Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.
Pereira RM, Ferreira-Silva GÁ, Pivatto M, Santos Lde Á, Bolzani Vda S, Chagas de Paula DA, Oliveira JC, Viegas Júnior C, Ionta M. Pereira RM, et al. Among authors: ionta m. Toxicol In Vitro. 2016 Mar;31:86-92. doi: 10.1016/j.tiv.2015.11.018. Epub 2015 Nov 23. Toxicol In Vitro. 2016. PMID: 26616281
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