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Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.
Pereira RM, Ferreira-Silva GÁ, Pivatto M, Santos Lde Á, Bolzani Vda S, Chagas de Paula DA, Oliveira JC, Viegas Júnior C, Ionta M. Pereira RM, et al. Among authors: ionta m. Toxicol In Vitro. 2016 Mar;31:86-92. doi: 10.1016/j.tiv.2015.11.018. Epub 2015 Nov 23. Toxicol In Vitro. 2016. PMID: 26616281
[Ru(pipe)(dppb)(bipy)]PF6: A novel ruthenium complex that effectively inhibits ERK activation and cyclin D1 expression in A549 cells.
Ferreira-Silva GA, Ortega MM, Banionis MA, Garavelli GY, Martins FT, Dias JSM, Viegas C Jr, Oliveira JC, Nascimento FBD, Doriguetto AC, Barbosa MIF, Ionta M. Ferreira-Silva GA, et al. Among authors: ionta m. Toxicol In Vitro. 2017 Oct;44:382-391. doi: 10.1016/j.tiv.2017.07.019. Epub 2017 Aug 1. Toxicol In Vitro. 2017. PMID: 28774850 Free article.
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