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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation.
Zhang T, Xu D, Liu J, Wang M, Duan LJ, Liu M, Meng H, Zhuang Y, Wang H, Wang Y, Lv M, Zhang Z, Hu J, Shi L, Guo R, Xie X, Liu H, Erickson E, Wang Y, Yu W, Dang F, Guan D, Jiang C, Dai X, Inuzuka H, Yan P, Wang J, Babuta M, Lian G, Tu Z, Miao J, Szabo G, Fong GH, Karnoub AE, Lee YR, Pan L, Kaelin WG Jr, Yuan J, Wei W. Zhang T, et al. Among authors: inuzuka h. Nat Cell Biol. 2023 Jul;25(7):950-962. doi: 10.1038/s41556-023-01170-4. Epub 2023 Jul 3. Nat Cell Biol. 2023. PMID: 37400498 Free PMC article.
A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609.
Tokumitsu H, Inuzuka H, Ishikawa Y, Kobayashi R. Tokumitsu H, et al. Among authors: inuzuka h. J Biol Chem. 2003 Mar 28;278(13):10908-13. doi: 10.1074/jbc.M213183200. Epub 2003 Jan 22. J Biol Chem. 2003. PMID: 12540834 Free article.
We recently developed STO-609, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase kinase (CaM-KK), and we demonstrated that CaM-KK beta is more sensitive to STO-609 than the CaM-KK alpha isoform (Tokumitsu H., Inuzuka H., Ishikawa Y., Ikeda M …
We recently developed STO-609, a selective inhibitor of Ca(2+)/calmodulin-dependent protein kinase kinase (CaM-KK), and we demonstrated that …
The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity.
Paquet M, Asay MJ, Fam SR, Inuzuka H, Castleberry AM, Oller H, Smith Y, Yun CC, Traynelis SF, Hall RA. Paquet M, et al. Among authors: inuzuka h. J Biol Chem. 2006 Oct 6;281(40):29949-61. doi: 10.1074/jbc.M602262200. Epub 2006 Aug 4. J Biol Chem. 2006. PMID: 16891310 Free PMC article.
Hunting the subset-specific genes of neuroblastoma: expression profiling and differential screening of the full-length-enriched oligo-capping cDNA libraries.
Ohira M, Shishikura T, Kawamoto T, Inuzuka H, Morohashi A, Takayasu H, Kageyama H, Takada N, Takahashi M, Sakiyama S, Suzuki Y, Sugano S, Kuma H, Nozawa I, Nakagawara A. Ohira M, et al. Among authors: inuzuka h. Med Pediatr Oncol. 2000 Dec;35(6):547-9. doi: 10.1002/1096-911x(20001201)35:6<547::aid-mpo11>3.0.co;2-x. Med Pediatr Oncol. 2000. PMID: 11107114
154 results