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G protein-dependent signaling triggers a β-arrestin-scaffolded p70S6K/ rpS6 module that controls 5'TOP mRNA translation.
Tréfier A, Musnier A, Landomiel F, Bourquard T, Boulo T, Ayoub MA, León K, Bruneau G, Chevalier M, Durand G, Blache MC, Inoue A, Fontaine J, Gauthier C, Tesseraud S, Reiter E, Poupon A, Crépieux P. Tréfier A, et al. Among authors: inoue a. FASEB J. 2018 Mar;32(3):1154-1169. doi: 10.1096/fj.201700763R. Epub 2018 Jan 3. FASEB J. 2018. PMID: 29084767
A., Leon, K., Bruneau, G., Chevalier, M., Durand, G., Blache, M.-C., Inoue, A., Fontaine, J., Gauthier, C., Tesseraud, S., Reiter, E., Poupon, A., Crepieux, P. ...
A., Leon, K., Bruneau, G., Chevalier, M., Durand, G., Blache, M.-C., Inoue, A., Fontaine, J., Gauthier, C., Tesseraud, …
Lack of beta-arrestin signaling in the absence of active G proteins.
Grundmann M, Merten N, Malfacini D, Inoue A, Preis P, Simon K, Rüttiger N, Ziegler N, Benkel T, Schmitt NK, Ishida S, Müller I, Reher R, Kawakami K, Inoue A, Rick U, Kühl T, Imhof D, Aoki J, König GM, Hoffmann C, Gomeza J, Wess J, Kostenis E. Grundmann M, et al. Among authors: inoue a. Nat Commun. 2018 Jan 23;9(1):341. doi: 10.1038/s41467-017-02661-3. Nat Commun. 2018. PMID: 29362459 Free PMC article.
BRET-based assay to monitor EGFR transactivation by the AT1R reveals Gq/11 protein-independent activation and AT1R-EGFR complexes.
O'Brien SL, Johnstone EKM, Devost D, Conroy J, Reichelt ME, Purdue BW, Ayoub MA, Kawai T, Inoue A, Eguchi S, Hébert TE, Pfleger KDG, Thomas WG. O'Brien SL, et al. Among authors: inoue a. Biochem Pharmacol. 2018 Dec;158:232-242. doi: 10.1016/j.bcp.2018.10.017. Epub 2018 Oct 19. Biochem Pharmacol. 2018. PMID: 30347205 Free PMC article.
Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation.
Mackenzie AE, Quon T, Lin LC, Hauser AS, Jenkins L, Inoue A, Tobin AB, Gloriam DE, Hudson BD, Milligan G. Mackenzie AE, et al. Among authors: inoue a. FASEB J. 2019 Apr;33(4):5005-5017. doi: 10.1096/fj.201801956R. Epub 2019 Jan 2. FASEB J. 2019. PMID: 30601679 Free PMC article.
These studies demonstrate that Galpha(13) is markedly the most effective G protein for interaction with GPR35 and that selection between Galpha(13) and Galpha(12) is dictated largely by a single conservative amino acid variation.-Mackenzie, A. E., Quon, T., Lin, L.- …
These studies demonstrate that Galpha(13) is markedly the most effective G protein for interaction with GPR35 and that selection between Gal …
Pharmacological Characterization of Low Molecular Weight Biased Agonists at the Follicle Stimulating Hormone Receptor.
De Pascali F, Ayoub MA, Benevelli R, Sposini S, Lehoux J, Gallay N, Raynaud P, Landomiel F, Jean-Alphonse F, Gauthier C, Pellissier LP, Crépieux P, Poupon A, Inoue A, Joubert N, Viaud-Massuard MC, Casarini L, Simoni M, Hanyaloglu AC, Nataraja SG, Yu HN, Palmer SS, Yvinec R, Reiter E. De Pascali F, et al. Among authors: inoue a. Int J Mol Sci. 2021 Sep 12;22(18):9850. doi: 10.3390/ijms22189850. Int J Mol Sci. 2021. PMID: 34576014 Free PMC article.
Serodolin, a β-arrestin-biased ligand of 5-HT7 receptor, attenuates pain-related behaviors.
El Khamlichi C, Reverchon F, Hervouet-Coste N, Robin E, Chopin N, Deau E, Madouri F, Guimpied C, Colas C, Menuet A, Inoue A, Bojarski AJ, Guillaumet G, Suzenet F, Reiter E, Morisset-Lopez S. El Khamlichi C, et al. Among authors: inoue a. Proc Natl Acad Sci U S A. 2022 May 24;119(21):e2118847119. doi: 10.1073/pnas.2118847119. Epub 2022 May 20. Proc Natl Acad Sci U S A. 2022. PMID: 35594393 Free PMC article.
2,542 results