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A selective p53 activator and anticancer agent to improve colorectal cancer therapy.
Ramos H, Soares MIL, Silva J, Raimundo L, Calheiros J, Gomes C, Reis F, Monteiro FA, Nunes C, Reis S, Bosco B, Piazza S, Domingues L, Chlapek P, Vlcek P, Fabian P, Rajado AT, Carvalho ATP, Veselska R, Inga A, Pinho E Melo TMVD, Saraiva L. Ramos H, et al. Among authors: inga a. Cell Rep. 2021 Apr 13;35(2):108982. doi: 10.1016/j.celrep.2021.108982. Cell Rep. 2021. PMID: 33852837 Free article.
Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53-MDM2 interaction.
Soares J, Pereira NA, Monteiro Â, Leão M, Bessa C, Dos Santos DJ, Raimundo L, Queiroz G, Bisio A, Inga A, Pereira C, Santos MM, Saraiva L. Soares J, et al. Among authors: inga a. Eur J Pharm Sci. 2015 Jan 23;66:138-47. doi: 10.1016/j.ejps.2014.10.006. Epub 2014 Oct 13. Eur J Pharm Sci. 2015. PMID: 25312347
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule.
Soares J, Raimundo L, Pereira NA, Monteiro Â, Gomes S, Bessa C, Pereira C, Queiroz G, Bisio A, Fernandes J, Gomes C, Reis F, Gonçalves J, Inga A, Santos MM, Saraiva L. Soares J, et al. Among authors: inga a. Oncotarget. 2016 Jan 26;7(4):4326-43. doi: 10.18632/oncotarget.6775. Oncotarget. 2016. PMID: 26735173 Free PMC article.
140 results