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Binding stoichiometry and structural model of the HIV-1 Rev/importin β complex.
Life Sci Alliance. 2022 Aug 22;5(10):e202201431. doi: 10.26508/lsa.202201431. Print 2022 Oct.
Life Sci Alliance. 2022.
PMID: 35995566
Free PMC article.
STLC-resistant cell lines as tools to classify chemically divergent Eg5 targeting agents according to their mode of action and target specificity.
Indorato RL, DeBonis S, Kozielski F, Garcia-Saez I, Skoufias DA.
Indorato RL, et al.
Biochem Pharmacol. 2013 Nov 15;86(10):1441-51. doi: 10.1016/j.bcp.2013.09.003. Epub 2013 Sep 13.
Biochem Pharmacol. 2013.
PMID: 24041742
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Drug resistance dependent on allostery: A P-loop rigor Eg5 mutant exhibits resistance to allosteric inhibition by STLC.
Indorato RL, DeBonis S, Garcia-Saez I, Skoufias DA.
Indorato RL, et al.
Front Oncol. 2022 Oct 12;12:965455. doi: 10.3389/fonc.2022.965455. eCollection 2022.
Front Oncol. 2022.
PMID: 36313676
Free PMC article.
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Is the Fate of Clinical Candidate Arry-520 Already Sealed? Predicting Resistance in Eg5-Inhibitor Complexes.
Indorato RL, Talapatra SK, Lin F, Haider S, Mackay SP, Kozielski F, Skoufias DA.
Indorato RL, et al.
Mol Cancer Ther. 2019 Dec;18(12):2394-2406. doi: 10.1158/1535-7163.MCT-19-0154. Epub 2019 Sep 5.
Mol Cancer Ther. 2019.
PMID: 31488701
Free article.
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Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed.
Skoufias DA, Indorato RL, Lacroix F, Panopoulos A, Margolis RL.
Skoufias DA, et al. Among authors: indorato rl.
J Cell Biol. 2007 Nov 19;179(4):671-85. doi: 10.1083/jcb.200704117.
J Cell Biol. 2007.
PMID: 18025303
Free PMC article.
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Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.
Kozielski F, Skoufias DA, Indorato RL, Saoudi Y, Jungblut PR, Hustoft HK, Strozynski M, Thiede B.
Kozielski F, et al. Among authors: indorato rl.
Proteomics. 2008 Jan;8(2):289-300. doi: 10.1002/pmic.200700534.
Proteomics. 2008.
PMID: 18186019
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Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5.
Debonis S, Skoufias DA, Indorato RL, Liger F, Marquet B, Laggner C, Joseph B, Kozielski F.
Debonis S, et al. Among authors: indorato rl.
J Med Chem. 2008 Mar 13;51(5):1115-25. doi: 10.1021/jm070606z. Epub 2008 Feb 12.
J Med Chem. 2008.
PMID: 18266314
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