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Post-exposure administration of diazepam combined with soluble epoxide hydrolase inhibition stops seizures and modulates neuroinflammation in a murine model of acute TETS intoxication.
Vito ST, Austin AT, Banks CN, Inceoglu B, Bruun DA, Zolkowska D, Tancredi DJ, Rogawski MA, Hammock BD, Lein PJ. Vito ST, et al. Among authors: inceoglu b. Toxicol Appl Pharmacol. 2014 Dec 1;281(2):185-94. doi: 10.1016/j.taap.2014.10.001. Epub 2014 Oct 14. Toxicol Appl Pharmacol. 2014. PMID: 25448683 Free PMC article.
Combined treatment with diazepam and allopregnanolone reverses tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures.
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. Bruun DA, et al. Among authors: inceoglu b. Neuropharmacology. 2015 Aug;95:332-42. doi: 10.1016/j.neuropharm.2015.03.035. Epub 2015 Apr 14. Neuropharmacology. 2015. PMID: 25882826 Free PMC article.
Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis.
Trindade-da-Silva CA, Bettaieb A, Napimoga MH, Lee KSS, Inceoglu B, Ueira-Vieira C, Bruun D, Goswami SK, Haj FG, Hammock BD. Trindade-da-Silva CA, et al. Among authors: inceoglu b. J Pharmacol Exp Ther. 2017 Jun;361(3):408-416. doi: 10.1124/jpet.116.238113. Epub 2017 Mar 29. J Pharmacol Exp Ther. 2017. PMID: 28356494 Free PMC article.
58 results