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Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors.
Satoh H, Ochi S, Mizuno K, Saga Y, Ujita S, Toyoda M, Nishiyama Y, Tada K, Matsushita Y, Deguchi Y, Suzuki K, Tanaka Y, Ueda H, Inaba T, Hosoi Y, Morita A, Aoki S. Satoh H, et al. Among authors: inaba t. Bioorg Med Chem. 2022 Aug 1;67:116764. doi: 10.1016/j.bmc.2022.116764. Epub 2022 May 9. Bioorg Med Chem. 2022. PMID: 35635928
AS-2, a novel inhibitor of p53-dependent apoptosis, prevents apoptotic mitochondrial dysfunction in a transcription-independent manner and protects mice from a lethal dose of ionizing radiation.
Morita A, Ariyasu S, Wang B, Asanuma T, Onoda T, Sawa A, Tanaka K, Takahashi I, Togami S, Nenoi M, Inaba T, Aoki S. Morita A, et al. Among authors: inaba t. Biochem Biophys Res Commun. 2014 Aug 8;450(4):1498-504. doi: 10.1016/j.bbrc.2014.07.037. Epub 2014 Jul 12. Biochem Biophys Res Commun. 2014. PMID: 25026551
A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist.
Morita A, Takahashi I, Sasatani M, Aoki S, Wang B, Ariyasu S, Tanaka K, Yamaguchi T, Sawa A, Nishi Y, Teraoka T, Ujita S, Kawate Y, Yanagawa C, Tanimoto K, Enomoto A, Nenoi M, Kamiya K, Nagata Y, Hosoi Y, Inaba T. Morita A, et al. Among authors: inaba t. Mol Cancer Ther. 2018 Feb;17(2):432-442. doi: 10.1158/1535-7163.MCT-16-0554. Epub 2017 Sep 22. Mol Cancer Ther. 2018. PMID: 28939557
A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis.
Morita A, Ochi S, Satoh H, Ujita S, Matsushita Y, Tada K, Toyoda M, Nishiyama Y, Mizuno K, Deguchi Y, Suzuki K, Tanaka Y, Ueda H, Inaba T, Hosoi Y, Aoki S. Morita A, et al. Among authors: inaba t. Life (Basel). 2021 Oct 15;11(10):1087. doi: 10.3390/life11101087. Life (Basel). 2021. PMID: 34685458 Free PMC article.
Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model.
Nakatsu Y, Otani Y, Sakoda H, Zhang J, Guo Y, Okubo H, Kushiyama A, Fujishiro M, Kikuch T, Fukushima T, Ohno H, Tsuchiya Y, Kamata H, Nagamachi A, Inaba T, Nishimura F, Katagiri H, Takahashi S, Kurihara H, Uchida T, Asano T. Nakatsu Y, et al. Among authors: inaba t. J Biol Chem. 2012 Dec 28;287(53):44526-35. doi: 10.1074/jbc.M112.397133. Epub 2012 Oct 29. J Biol Chem. 2012. PMID: 23112047 Free PMC article.
Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 Dysfunction.
Kobatake K, Ikeda KI, Nakata Y, Yamasaki N, Ueda T, Kanai A, Sentani K, Sera Y, Hayashi T, Koizumi M, Miyakawa Y, Inaba T, Sotomaru Y, Kaminuma O, Ichinohe T, Honda ZI, Yasui W, Horie S, Black PC, Matsubara A, Honda H. Kobatake K, et al. Among authors: inaba t. Clin Cancer Res. 2020 Apr 15;26(8):2065-2079. doi: 10.1158/1078-0432.CCR-19-2230. Epub 2020 Feb 11. Clin Cancer Res. 2020. PMID: 32047002
[Monosomy 7: recent progress].
Inaba T, Nagamachi A. Inaba T, et al. Rinsho Ketsueki. 2019;60(9):1020-1026. doi: 10.11406/rinketsu.60.1020. Rinsho Ketsueki. 2019. PMID: 31597823 Review. Japanese.
1,285 results