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Oxidative stress in metabolic dysfunction-associated steatotic liver disease (MASLD): How does the animal model resemble human disease?
Jakubek P, Kalinowski P, Karkucinska-Wieckowska A, Kaikini A, Simões ICM, Potes Y, Kruk B, Grajkowska W, Pinton P, Milkiewicz P, Grąt M, Pronicki M, Lebiedzinska-Arciszewska M, Krawczyk M, Wieckowski MR. Jakubek P, et al. Among authors: simoes icm. FASEB J. 2024 Feb 15;38(3):e23466. doi: 10.1096/fj.202302447R. FASEB J. 2024. PMID: 38318780
Oxidized cholesteryl ester induces exocytosis of dysfunctional lysosomes in lipidotic macrophages.
Domingues N, Marques ARA, Calado RDA, Ferreira IS, Ramos C, Ramalho J, Soares MIL, Pereira T, Oliveira L, Vicente JR, Wong LH, Simões ICM, Pinho E Melo TMVD, Peden A, Almeida CG, Futter CE, Puertollano R, Vaz WLC, Vieira OV. Domingues N, et al. Among authors: simoes icm. Traffic. 2023 Jul;24(7):284-307. doi: 10.1111/tra.12888. Epub 2023 May 2. Traffic. 2023. PMID: 37129279 Free article.
Mitochondria-targeted anti-oxidant AntiOxCIN4 improved liver steatosis in Western diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems.
Amorim R, Simões ICM, Teixeira J, Cagide F, Potes Y, Soares P, Carvalho A, Tavares LC, Benfeito S, Pereira SP, Simões RF, Karkucinska-Wieckowska A, Viegas I, Szymanska S, Dąbrowski M, Janikiewicz J, Cunha-Oliveira T, Dobrzyń A, Jones JG, Borges F, Wieckowski MR, Oliveira PJ. Amorim R, et al. Among authors: simoes icm. Redox Biol. 2022 Sep;55:102400. doi: 10.1016/j.redox.2022.102400. Epub 2022 Jul 16. Redox Biol. 2022. PMID: 35863265 Free PMC article.
MARC1 p.A165T variant is associated with decreased markers of liver injury and enhanced antioxidant capacity in autoimmune hepatitis.
Janik MK, Smyk W, Kruk B, Szczepankiewicz B, Górnicka B, Lebiedzińska-Arciszewska M, Potes Y, Simões ICM, Weber SN, Lammert F, Więckowski MR, Milkiewicz P, Krawczyk M. Janik MK, et al. Among authors: simoes icm. Sci Rep. 2021 Dec 23;11(1):24407. doi: 10.1038/s41598-021-03521-3. Sci Rep. 2021. PMID: 34949757 Free PMC article.
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship.
Karkucinska-Wieckowska A, Simoes ICM, Kalinowski P, Lebiedzinska-Arciszewska M, Zieniewicz K, Milkiewicz P, Górska-Ponikowska M, Pinton P, Malik AN, Krawczyk M, Oliveira PJ, Wieckowski MR. Karkucinska-Wieckowska A, et al. Among authors: simoes icm. Eur J Clin Invest. 2022 Mar;52(3):e13622. doi: 10.1111/eci.13622. Epub 2021 Jun 15. Eur J Clin Invest. 2022. PMID: 34050922 Review.
15 results