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Acylated 1H-1,2,4-Triazol-5-amines Targeting Human Coagulation Factor XIIa and Thrombin: Conventional and Microscale Synthesis, Anticoagulant Properties, and Mechanism of Action.
J Med Chem. 2020 Nov 12;63(21):13159-13186. doi: 10.1021/acs.jmedchem.0c01635. Epub 2020 Oct 22.
J Med Chem. 2020.
PMID: 33089691
Microscale Parallel Synthesis of Acylated Aminotriazoles Enabling the Development of Factor XIIa and Thrombin Inhibitors.
Platte S, Korff M, Imberg L, Balicioglu I, Erbacher C, Will JM, Daniliuc CG, Karst U, Kalinin DV.
Platte S, et al. Among authors: imberg l.
ChemMedChem. 2021 Dec 14;16(24):3672-3690. doi: 10.1002/cmdc.202100431. Epub 2021 Aug 4.
ChemMedChem. 2021.
PMID: 34278727
Free PMC article.
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N-Pyrazolyl- and N-Triazolylamines and -ureas as Antileishmanial and Antitrypanosomal Drugs.
Winge T, Imberg L, Perry B, Matheeusen A, Caljon G, Kalinin D, Wünsch B.
Winge T, et al. Among authors: imberg l.
ChemMedChem. 2024 Apr 30:e202400220. doi: 10.1002/cmdc.202400220. Online ahead of print.
ChemMedChem. 2024.
PMID: 38687962
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An automated analysis method enabling the screening of covalent thrombin and factor XIIa inhibitors via liquid chromatography-mass spectrometry.
Erbacher C, Athmer M, Kröger E, Dahrendorf L, Imberg L, Kalinin DV, Karst U.
Erbacher C, et al. Among authors: imberg l.
Drug Test Anal. 2024 Mar;16(3):314-322. doi: 10.1002/dta.3549. Epub 2023 Jul 21.
Drug Test Anal. 2024.
PMID: 37482900
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Amide-functionalized 1,2,4-Triazol-5-amines as Covalent Inhibitors of Blood Coagulation Factor XIIa and Thrombin.
Imberg L, Platte S, Erbacher C, Daniliuc CG, Kalinina SA, Dörner W, Poso A, Karst U, Kalinin DV.
Imberg L, et al.
ACS Pharmacol Transl Sci. 2022 Nov 30;5(12):1318-1347. doi: 10.1021/acsptsci.2c00204. eCollection 2022 Dec 9.
ACS Pharmacol Transl Sci. 2022.
PMID: 36524012
Free PMC article.
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Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity.
Dunker C, Imberg L, Siutkina AI, Erbacher C, Daniliuc CG, Karst U, Kalinin DV.
Dunker C, et al. Among authors: imberg l.
Pharmaceuticals (Basel). 2022 Oct 28;15(11):1340. doi: 10.3390/ph15111340.
Pharmaceuticals (Basel). 2022.
PMID: 36355511
Free PMC article.
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