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Intracerebroventricular administration of CYX-6, a potent μ-opioid receptor agonist, a δ- and κ-opioid receptor antagonist and a biased ligand at μ, δ & κ-opioid receptors, evokes antinociception with minimal constipation and respiratory depression in rats in contrast to morphine.
Imam MZ, Kuo A, Ghassabian S, Cai Y, Qin Y, Li T, Smith MT. Imam MZ, et al. Eur J Pharmacol. 2020 Mar 15;871:172918. doi: 10.1016/j.ejphar.2020.172918. Epub 2020 Jan 17. Eur J Pharmacol. 2020. PMID: 31958457
J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine.
Kuo A, Imam MZ, Li R, Lin L, Raboczyj A, Bohmer AE, Nicholson JR, Corradini L, Smith MT. Kuo A, et al. Among authors: imam mz. Front Pharmacol. 2024 Jan 22;15:1346801. doi: 10.3389/fphar.2024.1346801. eCollection 2024. Front Pharmacol. 2024. PMID: 38318132 Free PMC article.
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