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The Role of Lysosomes in a Broad Disease-Modifying Approach Evaluated across Transgenic Mouse Models of Alzheimer's Disease and Parkinson's Disease and Models of Mild Cognitive Impairment.
Hwang J, Estick CM, Ikonne US, Butler D, Pait MC, Elliott LH, Ruiz S, Smith K, Rentschler KM, Mundell C, Almeida MF, Stumbling Bear N, Locklear JP, Abumohsen Y, Ivey CM, Farizatto KLG, Bahr BA. Hwang J, et al. Among authors: ikonne us. Int J Mol Sci. 2019 Sep 9;20(18):4432. doi: 10.3390/ijms20184432. Int J Mol Sci. 2019. PMID: 31505809 Free PMC article.
Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.
Farizatto KLG, Ikonne US, Almeida MF, Ferrari MFR, Bahr BA. Farizatto KLG, et al. Among authors: ikonne us. PLoS One. 2017 Aug 10;12(8):e0182895. doi: 10.1371/journal.pone.0182895. eCollection 2017. PLoS One. 2017. PMID: 28797057 Free PMC article.