Ihnat M - Search Results

1

The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents.

Zhang X, Raghavan S, Ihnat M, Thorpe JE, Disch BC, Bastian A, Bailey-Downs LC, Dybdal-Hargreaves NF, Rohena CC, Hamel E, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: ihnat m. Bioorg Med Chem. 2014 Jul 15;22(14):3753-72. doi: 10.1016/j.bmc.2014.04.049. Epub 2014 May 14. Bioorg Med Chem. 2014. PMID: 24890652 Free PMC article.

2

Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity.

Gangjee A, Zeng Y, Ihnat M, Warnke LA, Green DW, Kisliuk RL, Lin FT. Gangjee A, et al. Among authors: ihnat m. Bioorg Med Chem. 2005 Sep 15;13(18):5475-91. doi: 10.1016/j.bmc.2005.04.087. Bioorg Med Chem. 2005. PMID: 16039863

3

Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.

Gangjee A, Li W, Lin L, Zeng Y, Ihnat M, Warnke LA, Green DW, Cody V, Pace J, Queener SF. Gangjee A, et al. Among authors: ihnat m. Bioorg Med Chem. 2009 Oct 15;17(20):7324-36. doi: 10.1016/j.bmc.2009.08.044. Epub 2009 Aug 22. Bioorg Med Chem. 2009. PMID: 19748785 Free PMC article.

4

Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Gangjee A, Zaware N, Raghavan S, Ihnat M, Shenoy S, Kisliuk RL. Gangjee A, et al. Among authors: ihnat m. J Med Chem. 2010 Feb 25;53(4):1563-78. doi: 10.1021/jm9011142. J Med Chem. 2010. PMID: 20092323 Free PMC article.

5

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents.

Zhang X, Raghavan S, Ihnat M, Hamel E, Zammiello C, Bastian A, Mooberry SL, Gangjee A. Zhang X, et al. Among authors: ihnat m. Bioorg Med Chem. 2015 May 15;23(10):2408-23. doi: 10.1016/j.bmc.2015.03.061. Epub 2015 Mar 30. Bioorg Med Chem. 2015. PMID: 25882519 Free PMC article.

6

Design, synthesis and preclinical evaluation of 5-methyl-N⁴-aryl-furo[2,3-d]pyrimidines as single agents with combination chemotherapy potential.

Devambatla RKV, Choudhary S, Ihnat M, Hamel E, Mooberry SL, Gangjee A. Devambatla RKV, et al. Among authors: ihnat m. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3085-3093. doi: 10.1016/j.bmcl.2018.07.039. Epub 2018 Jul 27. Bioorg Med Chem Lett. 2018. PMID: 30098869

7

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.

Choudhary S, Doshi A, Luckett-Chastain L, Ihnat M, Hamel E, Mooberry SL, Gangjee A. Choudhary S, et al. Among authors: ihnat m. Bioorg Med Chem. 2021 Apr 1;35:116061. doi: 10.1016/j.bmc.2021.116061. Epub 2021 Feb 12. Bioorg Med Chem. 2021. PMID: 33647840 Free PMC article.

8

Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.

Gangjee A, Yang J, Ihnat MA, Kamat S. Gangjee A, et al. Bioorg Med Chem. 2003 Nov 17;11(23):5155-70. doi: 10.1016/j.bmc.2003.08.034. Bioorg Med Chem. 2003. PMID: 14604679

9

Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.

Gangjee A, Namjoshi OA, Yu J, Ihnat MA, Thorpe JE, Warnke LA. Gangjee A, et al. Bioorg Med Chem. 2008 May 15;16(10):5514-28. doi: 10.1016/j.bmc.2008.04.019. Epub 2008 Apr 14. Bioorg Med Chem. 2008. PMID: 18467105 Free PMC article.

10

The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.

Gangjee A, Namjoshi OA, Ihnat MA, Buchanan A. Gangjee A, et al. Bioorg Med Chem Lett. 2010 May 15;20(10):3177-81. doi: 10.1016/j.bmcl.2010.03.064. Epub 2010 Mar 24. Bioorg Med Chem Lett. 2010. PMID: 20403693 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

115 results

Search Page