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Showing results for ikaros d
Search for Iharos D instead (1 results)
Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells.
Park SM, Miyamoto DK, Han GYQ, Chan M, Curnutt NM, Tran NL, Velleca A, Kim JH, Schurer A, Chang K, Xu W, Kharas MG, Woo CM. Park SM, et al. Cancer Cell. 2023 Apr 10;41(4):726-739.e11. doi: 10.1016/j.ccell.2023.02.010. Epub 2023 Mar 9. Cancer Cell. 2023. PMID: 36898380 Free PMC article.
GSK3beta-Ikaros-ANXA4 signaling inhibits high-glucose-induced fibroblast migration.
Wang Y, Zheng X, Wang Q, Zheng M, Pang L. Wang Y, et al. Biochem Biophys Res Commun. 2020 Oct 22;531(4):543-551. doi: 10.1016/j.bbrc.2020.07.142. Epub 2020 Aug 14. Biochem Biophys Res Commun. 2020. PMID: 32807499
Besides, GSK3beta Ser(9)D, but not GSK3beta Ser(9)A, activated Ikaros Ser(391) phosphorylation. ...The expression of the phosphomimic form of Ikaros Ser(391)D resulted in a significant increase in the extent of cell migration compared with Ikaros …
Besides, GSK3beta Ser(9)D, but not GSK3beta Ser(9)A, activated Ikaros Ser(391) phosphorylation. ...The expression of the phosp …
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Bonazzi S, d'Hennezel E, Beckwith REJ, Xu L, Fazal A, Magracheva A, Ramesh R, Cernijenko A, Antonakos B, Bhang HC, Caro RG, Cobb JS, Ornelas E, Ma X, Wartchow CA, Clifton MC, Forseth RR, Fortnam BH, Lu H, Csibi A, Tullai J, Carbonneau S, Thomsen NM, Larrow J, Chie-Leon B, Hainzl D, Gu Y, Lu D, Meyer MJ, Alexander D, Kinyamu-Akunda J, Sabatos-Peyton CA, Dales NA, Zécri FJ, Jain RK, Shulok J, Wang YK, Briner K, Porter JA, Tallarico JA, Engelman JA, Dranoff G, Bradner JE, Visser M, Solomon JM. Bonazzi S, et al. Cell Chem Biol. 2023 Mar 16;30(3):235-247.e12. doi: 10.1016/j.chembiol.2023.02.005. Epub 2023 Mar 1. Cell Chem Biol. 2023. PMID: 36863346 Free article.
Ikaros gene expression and leukemia.
Tonnelle C, Calmels B, Maroc C, Gabert J, Chabannon C. Tonnelle C, et al. Leuk Lymphoma. 2002 Jan;43(1):29-35. doi: 10.1080/10428190210186. Leuk Lymphoma. 2002. PMID: 11908734 Review.
The Ikaros (Ik) protein, or LyF1, was initially described as a protein binding to regulatory sequences of a number of genes expressed in murine lymphoid cells. Ikaros is a critical regulator of normal hematopoietic stem cell differentiation, as evidenced by dramatic …
The Ikaros (Ik) protein, or LyF1, was initially described as a protein binding to regulatory sequences of a number of genes expressed …
Ikaros antagonizes DNA binding by STAT5 in pre-B cells.
Heizmann B, Le Gras S, Simand C, Marchal P, Chan S, Kastner P. Heizmann B, et al. PLoS One. 2020 Nov 12;15(11):e0242211. doi: 10.1371/journal.pone.0242211. eCollection 2020. PLoS One. 2020. PMID: 33180866 Free PMC article.
Strikingly, Ikaros activity leads to widespread loss of STAT5 binding at most of its genomic targets within two hours of Ikaros induction, suggesting a direct mechanism. Ikaros did not alter the level of total or phosphorylated STAT5 proteins, nor did it asso …
Strikingly, Ikaros activity leads to widespread loss of STAT5 binding at most of its genomic targets within two hours of Ikaros …
Ikaros, Aiolos and Helios: transcription regulators and lymphoid malignancies.
Rebollo A, Schmitt C. Rebollo A, et al. Immunol Cell Biol. 2003 Jun;81(3):171-5. doi: 10.1046/j.1440-1711.2003.01159.x. Immunol Cell Biol. 2003. PMID: 12752680 Review.
Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation. ...Several reports reinforce the hypothesis that Ikaros, Aiolos and Helios expression is deregulated in human leukaemias. .. …
Ikaros, Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differen …
Metabolic gatekeeper function of B-lymphoid transcription factors.
Chan LN, Chen Z, Braas D, Lee JW, Xiao G, Geng H, Cosgun KN, Hurtz C, Shojaee S, Cazzaniga V, Schjerven H, Ernst T, Hochhaus A, Kornblau SM, Konopleva M, Pufall MA, Cazzaniga G, Liu GJ, Milne TA, Koeffler HP, Ross TS, Sánchez-García I, Borkhardt A, Yamamoto KR, Dickins RA, Graeber TG, Müschen M. Chan LN, et al. Nature. 2017 Feb 23;542(7642):479-483. doi: 10.1038/nature21076. Epub 2017 Feb 13. Nature. 2017. PMID: 28192788 Free PMC article.
Ikaros prevents autoimmunity by controlling anergy and Toll-like receptor signaling in B cells.
Schwickert TA, Tagoh H, Schindler K, Fischer M, Jaritz M, Busslinger M. Schwickert TA, et al. Nat Immunol. 2019 Nov;20(11):1517-1529. doi: 10.1038/s41590-019-0490-2. Epub 2019 Oct 7. Nat Immunol. 2019. PMID: 31591571 Free PMC article.
Here, we describe a critical role of the transcription factor Ikaros in controlling BCR anergy and TLR signaling. Mice with specific deletion of Ikaros in mature B cells developed systemic autoimmunity. Ikaros regulated many anergy-associated genes, including …
Here, we describe a critical role of the transcription factor Ikaros in controlling BCR anergy and TLR signaling. Mice with specific …
Phase 2 Trial of Iberdomide in Systemic Lupus Erythematosus.
Merrill JT, Werth VP, Furie R, van Vollenhoven R, Dörner T, Petronijevic M, Velasco J, Majdan M, Irazoque-Palazuelos F, Weiswasser M, Korish S, Ye Y, Gaudy A, Schafer PH, Liu Z, Agafonova N, Delev N. Merrill JT, et al. N Engl J Med. 2022 Mar 17;386(11):1034-1045. doi: 10.1056/NEJMoa2106535. N Engl J Med. 2022. PMID: 35294813 Clinical Trial.
BACKGROUND: Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being evaluated for the treatment of systemic lupus erythematosus (SLE). ...
BACKGROUND: Iberdomide, a cereblon modulator promoting degradation of the transcription factors Ikaros and Aiolos, which affect leuko …
Ikaros Is a Negative Regulator of B1 Cell Development and Function.
Macias-Garcia A, Heizmann B, Sellars M, Marchal P, Dali H, Pasquali JL, Muller S, Kastner P, Chan S. Macias-Garcia A, et al. J Biol Chem. 2016 Apr 22;291(17):9073-86. doi: 10.1074/jbc.M115.704239. Epub 2016 Feb 3. J Biol Chem. 2016. PMID: 26841869 Free PMC article.
Ikaros-null B1 cells hyper-react to TLR4 stimulation and secrete high amounts of IgM autoantibodies. These results indicate that Ikaros is required to limit B1 cell homeostasis in the adult....
Ikaros-null B1 cells hyper-react to TLR4 stimulation and secrete high amounts of IgM autoantibodies. These results indicate that I …
117 results