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Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway.
Parra V, Verdejo HE, Iglewski M, Del Campo A, Troncoso R, Jones D, Zhu Y, Kuzmicic J, Pennanen C, Lopez-Crisosto C, Jaña F, Ferreira J, Noguera E, Chiong M, Bernlohr DA, Klip A, Hill JA, Rothermel BA, Abel ED, Zorzano A, Lavandero S. Parra V, et al. Among authors: iglewski m. Diabetes. 2014 Jan;63(1):75-88. doi: 10.2337/db13-0340. Epub 2013 Sep 5. Diabetes. 2014. PMID: 24009260 Free PMC article.
Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.
Battiprolu PK, Hojayev B, Jiang N, Wang ZV, Luo X, Iglewski M, Shelton JM, Gerard RD, Rothermel BA, Gillette TG, Lavandero S, Hill JA. Battiprolu PK, et al. Among authors: iglewski m. J Clin Invest. 2012 Mar;122(3):1109-18. doi: 10.1172/JCI60329. Epub 2012 Feb 13. J Clin Invest. 2012. PMID: 22326951 Free PMC article.
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.
Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Bravo R, et al. Among authors: iglewski m. J Cell Sci. 2011 Jul 1;124(Pt 13):2143-52. doi: 10.1242/jcs.080762. Epub 2011 May 31. J Cell Sci. 2011. PMID: 21628424 Free PMC article.
The complex interplay between mitochondrial dynamics and cardiac metabolism.
Parra V, Verdejo H, del Campo A, Pennanen C, Kuzmicic J, Iglewski M, Hill JA, Rothermel BA, Lavandero S. Parra V, et al. Among authors: iglewski m. J Bioenerg Biomembr. 2011 Feb;43(1):47-51. doi: 10.1007/s10863-011-9332-0. J Bioenerg Biomembr. 2011. PMID: 21258852 Free PMC article. Review.