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Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ2.5 complexes in the context of celiac disease.
Okura Y, Ikawa-Teranishi Y, Mizoroki A, Takahashi N, Tsushima T, Irie M, Harfuddin Z, Miura-Okuda M, Ito S, Nakamura G, Takesue H, Ozono Y, Nishihara M, Yamada K, Gan SW, Hayasaka A, Ishii S, Wakabayashi T, Muraoka M, Nagaya N, Hino H, Nemoto T, Kuramochi T, Torizawa T, Shimada H, Kitazawa T, Okazaki M, Nezu J, Sollid LM, Igawa T. Okura Y, et al. Among authors: igawa t. Nat Commun. 2023 Dec 22;14(1):8502. doi: 10.1038/s41467-023-44083-4. Nat Commun. 2023. PMID: 38135691 Free PMC article.
Antibody recycling by engineered pH-dependent antigen binding improves the duration of antigen neutralization.
Igawa T, Ishii S, Tachibana T, Maeda A, Higuchi Y, Shimaoka S, Moriyama C, Watanabe T, Takubo R, Doi Y, Wakabayashi T, Hayasaka A, Kadono S, Miyazaki T, Haraya K, Sekimori Y, Kojima T, Nabuchi Y, Aso Y, Kawabe Y, Hattori K. Igawa T, et al. Nat Biotechnol. 2010 Nov;28(11):1203-7. doi: 10.1038/nbt.1691. Epub 2010 Oct 17. Nat Biotechnol. 2010. PMID: 20953198
A bispecific antibody to factors IXa and X restores factor VIII hemostatic activity in a hemophilia A model.
Kitazawa T, Igawa T, Sampei Z, Muto A, Kojima T, Soeda T, Yoshihashi K, Okuyama-Nishida Y, Saito H, Tsunoda H, Suzuki T, Adachi H, Miyazaki T, Ishii S, Kamata-Sakurai M, Iida T, Harada A, Esaki K, Funaki M, Moriyama C, Tanaka E, Kikuchi Y, Wakabayashi T, Wada M, Goto M, Toyoda T, Ueyama A, Suzuki S, Haraya K, Tachibana T, Kawabe Y, Shima M, Yoshioka A, Hattori K. Kitazawa T, et al. Among authors: igawa t. Nat Med. 2012 Oct;18(10):1570-4. doi: 10.1038/nm.2942. Epub 2012 Sep 30. Nat Med. 2012. PMID: 23023498
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.
Sampei Z, Igawa T, Soeda T, Okuyama-Nishida Y, Moriyama C, Wakabayashi T, Tanaka E, Muto A, Kojima T, Kitazawa T, Yoshihashi K, Harada A, Funaki M, Haraya K, Tachibana T, Suzuki S, Esaki K, Nabuchi Y, Hattori K. Sampei Z, et al. Among authors: igawa t. PLoS One. 2013;8(2):e57479. doi: 10.1371/journal.pone.0057479. Epub 2013 Feb 28. PLoS One. 2013. PMID: 23468998 Free PMC article.
Engineered monoclonal antibody with novel antigen-sweeping activity in vivo.
Igawa T, Maeda A, Haraya K, Tachibana T, Iwayanagi Y, Mimoto F, Higuchi Y, Ishii S, Tamba S, Hironiwa N, Nagano K, Wakabayashi T, Tsunoda H, Hattori K. Igawa T, et al. PLoS One. 2013 May 7;8(5):e63236. doi: 10.1371/journal.pone.0063236. Print 2013. PLoS One. 2013. PMID: 23667591 Free PMC article.
415 results