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Serum metabolomics reveals γ-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease.
Soga T, Sugimoto M, Honma M, Mori M, Igarashi K, Kashikura K, Ikeda S, Hirayama A, Yamamoto T, Yoshida H, Otsuka M, Tsuji S, Yatomi Y, Sakuragawa T, Watanabe H, Nihei K, Saito T, Kawata S, Suzuki H, Tomita M, Suematsu M. Soga T, et al. Among authors: igarashi k. J Hepatol. 2011 Oct;55(4):896-905. doi: 10.1016/j.jhep.2011.01.031. Epub 2011 Feb 18. J Hepatol. 2011. PMID: 21334394 Clinical Trial.
Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways.
Valli A, Rodriguez M, Moutsianas L, Fischer R, Fedele V, Huang HL, Van Stiphout R, Jones D, Mccarthy M, Vinaxia M, Igarashi K, Sato M, Soga T, Buffa F, Mccullagh J, Yanes O, Harris A, Kessler B. Valli A, et al. Among authors: igarashi k. Oncotarget. 2015 Feb 10;6(4):1920-41. doi: 10.18632/oncotarget.3058. Oncotarget. 2015. PMID: 25605240 Free PMC article.
Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC.
Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T. Satoh K, et al. Among authors: igarashi k. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7697-E7706. doi: 10.1073/pnas.1710366114. Epub 2017 Aug 28. Proc Natl Acad Sci U S A. 2017. PMID: 28847964 Free PMC article.
Perioperative serum and urine metabolome analyses in patients with hepatocellular carcinoma undergoing partial hepatectomy.
Kajiura D, Yamanaka-Okumura H, Hirayama A, Tatano H, Endo K, Honma M, Igarashi K, Shoji F, Ikeda S, Yamaguchi N, Katayama T, Morine Y, Imura S, Utsunomiya T, Soga T, Tomita M, Shimada M. Kajiura D, et al. Among authors: igarashi k. Nutrition. 2019 Feb;58:110-119. doi: 10.1016/j.nut.2018.06.002. Epub 2018 Aug 7. Nutrition. 2019. PMID: 30391689
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2.
Nishimura T, Nakata A, Chen X, Nishi K, Meguro-Horike M, Sasaki S, Kita K, Horike SI, Saitoh K, Kato K, Igarashi K, Murayama T, Kohno S, Takahashi C, Mukaida N, Yano S, Soga T, Tojo A, Gotoh N. Nishimura T, et al. Among authors: igarashi k. Oncogene. 2019 Apr;38(14):2464-2481. doi: 10.1038/s41388-018-0589-1. Epub 2018 Dec 7. Oncogene. 2019. PMID: 30532069 Free PMC article.
2,150 results