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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou YS, Ueno I, Sakamoto A, Tong KI, Kim M, Nishito Y, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M. Komatsu M, et al. Among authors: iemura s. Nat Cell Biol. 2010 Mar;12(3):213-23. doi: 10.1038/ncb2021. Epub 2010 Feb 21. Nat Cell Biol. 2010. PMID: 20173742
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice.
Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. Komatsu M, et al. Among authors: iemura s. Cell. 2007 Dec 14;131(6):1149-63. doi: 10.1016/j.cell.2007.10.035. Cell. 2007. PMID: 18083104 Free article.
A novel type of E3 ligase for the Ufm1 conjugation system.
Tatsumi K, Sou YS, Tada N, Nakamura E, Iemura S, Natsume T, Kang SH, Chung CH, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M. Tatsumi K, et al. Among authors: iemura s. J Biol Chem. 2010 Feb 19;285(8):5417-27. doi: 10.1074/jbc.M109.036814. Epub 2009 Dec 14. J Biol Chem. 2010. PMID: 20018847 Free PMC article.
117 results