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Metabotropic Glutamate Receptor 2 Expression Is Chronically Elevated in Male Rats With Post-Traumatic Stress Disorder Related Behavioral Traits Following Repetitive Low-Level Blast Exposure.
De Gasperi R, Gama Sosa MA, Perez Garcia G, Perez GM, Pryor D, Morrison CL, Lind R, Abutarboush R, Kawoos U, Statz JK, Patterson J, Hof PR, Zhu CW, Ahlers ST, Cook DG, Elder GA. De Gasperi R, et al. J Neurotrauma. 2024 Mar;41(5-6):714-733. doi: 10.1089/neu.2023.0252. Epub 2023 Dec 19. J Neurotrauma. 2024. PMID: 37917117
BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy.
Perez-Garcia G, Bicak M, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Barlow C, Gage FH, Readhead B, Ehrlich ME, Gandy S, Elder GA. Perez-Garcia G, et al. Neurosci Lett. 2023 Feb 16;797:137080. doi: 10.1016/j.neulet.2023.137080. Epub 2023 Jan 16. Neurosci Lett. 2023. PMID: 36657633 Free PMC article.
Engagement of vascular early response genes typifies mild cognitive impairment.
Katsel P, Fam P, Tan W, Khan S, Gama-Sosa M, De Gasperi R, Roussos P, Robinson A, Cooper I, Schnaider-Beeri M, Haroutunian V. Katsel P, et al. Alzheimers Dement. 2022 Jul;18(7):1357-1369. doi: 10.1002/alz.12481. Epub 2021 Nov 10. Alzheimers Dement. 2022. PMID: 34758195 Free PMC article.
Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation.
Gama Sosa MA, De Gasperi R, Pryor D, Perez Garcia GS, Perez GM, Abutarboush R, Kawoos U, Hogg S, Ache B, Janssen WG, Sowa A, Tetreault T, Cook DG, Tappan SJ, Gandy S, Hof PR, Ahlers ST, Elder GA. Gama Sosa MA, et al. Acta Neuropathol Commun. 2021 Oct 15;9(1):167. doi: 10.1186/s40478-021-01269-5. Acta Neuropathol Commun. 2021. PMID: 34654480 Free PMC article.