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BCI-838, an orally active mGluR2/3 receptor antagonist pro-drug, rescues learning behavior deficits in the PS19 MAPTP301S mouse model of tauopathy.
Perez-Garcia G, Bicak M, Haure-Mirande JV, Perez GM, Otero-Pagan A, Gama Sosa MA, De Gasperi R, Sano M, Barlow C, Gage FH, Readhead B, Ehrlich ME, Gandy S, Elder GA. Perez-Garcia G, et al. Neurosci Lett. 2023 Feb 16;797:137080. doi: 10.1016/j.neulet.2023.137080. Epub 2023 Jan 16. Neurosci Lett. 2023. PMID: 36657633 Free PMC article.
Alzheimer mutant speeds APP transport.
Gandy S, Ehrlich ME. Gandy S, et al. J Exp Med. 2021 Jun 7;218(6):e20210511. doi: 10.1084/jem.20210511. Epub 2021 May 14. J Exp Med. 2021. PMID: 33988687 Free PMC article.
Laterality and region-specific tau phosphorylation correlate with PTSD-related behavioral traits in rats exposed to repetitive low-level blast.
Perez Garcia G, De Gasperi R, Gama Sosa MA, Perez GM, Otero-Pagan A, Pryor D, Abutarboush R, Kawoos U, Hof PR, Dickstein DL, Cook DG, Gandy S, Ahlers ST, Elder GA. Perez Garcia G, et al. Acta Neuropathol Commun. 2021 Mar 1;9(1):33. doi: 10.1186/s40478-021-01128-3. Acta Neuropathol Commun. 2021. PMID: 33648608 Free PMC article.
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure.
Dickstein DL, De Gasperi R, Gama Sosa MA, Perez-Garcia G, Short JA, Sosa H, Perez GM, Tschiffely AE, Dams-O'Connor K, Pullman MY, Knesaurek K, Knutsen A, Pham DL, Soleimani L, Jordan BD, Gordon WA, Delman BN, Shumyatsky G, Shahim PP, DeKosky ST, Stone JR, Peskind E, Blennow K, Zetterberg H, Chance SA, Torso M, Kostakoglu L, Sano M, Hof PR, Ahlers ST, Gandy S, Elder GA. Dickstein DL, et al. Mol Psychiatry. 2021 Oct;26(10):5940-5954. doi: 10.1038/s41380-020-0674-z. Epub 2020 Feb 25. Mol Psychiatry. 2021. PMID: 32094584 Free PMC article.
Low-level blast exposure disrupts gliovascular and neurovascular connections and induces a chronic vascular pathology in rat brain.
Gama Sosa MA, De Gasperi R, Perez Garcia GS, Perez GM, Searcy C, Vargas D, Spencer A, Janssen PL, Tschiffely AE, McCarron RM, Ache B, Manoharan R, Janssen WG, Tappan SJ, Hanson RW, Gandy S, Hof PR, Ahlers ST, Elder GA. Gama Sosa MA, et al. Acta Neuropathol Commun. 2019 Jan 9;7(1):6. doi: 10.1186/s40478-018-0647-5. Acta Neuropathol Commun. 2019. PMID: 30626447 Free PMC article.
Blast-induced "PTSD": Evidence from an animal model.
Perez-Garcia G, Gama Sosa MA, De Gasperi R, Tschiffely AE, McCarron RM, Hof PR, Gandy S, Ahlers ST, Elder GA. Perez-Garcia G, et al. Neuropharmacology. 2019 Feb;145(Pt B):220-229. doi: 10.1016/j.neuropharm.2018.09.023. Epub 2018 Sep 15. Neuropharmacology. 2019. PMID: 30227150 Review.
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