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Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.
Nain-Perez A, Foller Füchtbauer A, Håversen L, Lulla A, Gao C, Matic J, Monjas L, Rodríguez A, Brear P, Kim W, Hyvönen M, Borén J, Mardinoglu A, Uhlen M, Grøtli M. Nain-Perez A, et al. Among authors: hyvonen m. Eur J Med Chem. 2022 Apr 15;234:114270. doi: 10.1016/j.ejmech.2022.114270. Epub 2022 Mar 8. Eur J Med Chem. 2022. PMID: 35290845 Free article.
Specific inhibition of CK2α from an anchor outside the active site.
Brear P, De Fusco C, Hadje Georgiou K, Francis-Newton NJ, Stubbs CJ, Sore HF, Venkitaraman AR, Abell C, Spring DR, Hyvönen M. Brear P, et al. Among authors: hyvonen m. Chem Sci. 2016 Nov 1;7(11):6839-6845. doi: 10.1039/c6sc02335e. Epub 2016 Jul 12. Chem Sci. 2016. PMID: 28451126 Free PMC article.
Second-generation CK2α inhibitors targeting the αD pocket.
Iegre J, Brear P, De Fusco C, Yoshida M, Mitchell SL, Rossmann M, Carro L, Sore HF, Hyvönen M, Spring DR. Iegre J, et al. Among authors: hyvonen m. Chem Sci. 2018 Feb 20;9(11):3041-3049. doi: 10.1039/c7sc05122k. eCollection 2018 Mar 21. Chem Sci. 2018. PMID: 29732088 Free PMC article.
Novel non-ATP competitive small molecules targeting the CK2 α/β interface.
Brear P, North A, Iegre J, Hadje Georgiou K, Lubin A, Carro L, Green W, Sore HF, Hyvönen M, Spring DR. Brear P, et al. Among authors: hyvonen m. Bioorg Med Chem. 2018 Jul 15;26(11):3016-3020. doi: 10.1016/j.bmc.2018.05.011. Epub 2018 May 9. Bioorg Med Chem. 2018. PMID: 29759799 Free PMC article.
Proposed Allosteric Inhibitors Bind to the ATP Site of CK2α.
Brear P, Ball D, Stott K, D'Arcy S, Hyvönen M. Brear P, et al. Among authors: hyvonen m. J Med Chem. 2020 Nov 12;63(21):12786-12798. doi: 10.1021/acs.jmedchem.0c01173. Epub 2020 Oct 29. J Med Chem. 2020. PMID: 33119282 Free PMC article.
Development of small cyclic peptides targeting the CK2α/β interface.
Atkinson EL, Iegre J, D'Amore C, Brear P, Salvi M, Hyvönen M, Spring DR. Atkinson EL, et al. Among authors: hyvonen m. Chem Commun (Camb). 2022 Apr 12;58(30):4791-4794. doi: 10.1039/d2cc00707j. Chem Commun (Camb). 2022. PMID: 35343996 Free PMC article.
202 results