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Tau protein liquid-liquid phase separation can initiate tau aggregation.
Wegmann S, Eftekharzadeh B, Tepper K, Zoltowska KM, Bennett RE, Dujardin S, Laskowski PR, MacKenzie D, Kamath T, Commins C, Vanderburg C, Roe AD, Fan Z, Molliex AM, Hernandez-Vega A, Muller D, Hyman AA, Mandelkow E, Taylor JP, Hyman BT. Wegmann S, et al. Among authors: hyman aa, hyman bt. EMBO J. 2018 Apr 3;37(7):e98049. doi: 10.15252/embj.201798049. Epub 2018 Feb 22. EMBO J. 2018. PMID: 29472250 Free PMC article.
No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain.
Ingelsson M, Ramasamy K, Cantuti-Castelvetri I, Skoglund L, Matsui T, Orne J, Kowa H, Raju S, Vanderburg CR, Augustinack JC, de Silva R, Lees AJ, Lannfelt L, Growdon JH, Frosch MP, Standaert DG, Irizarry MC, Hyman BT. Ingelsson M, et al. Among authors: hyman bt. Acta Neuropathol. 2006 Oct;112(4):439-49. doi: 10.1007/s00401-006-0095-3. Epub 2006 Jun 27. Acta Neuropathol. 2006. PMID: 16802167
Tau pathophysiology in neurodegeneration: a tangled issue.
Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT. Spires-Jones TL, et al. Among authors: hyman bt. Trends Neurosci. 2009 Mar;32(3):150-9. doi: 10.1016/j.tins.2008.11.007. Epub 2009 Jan 21. Trends Neurosci. 2009. PMID: 19162340 Review.
833 results