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Prenatal smoke exposure induces persistent Cyp2a5 methylation and increases nicotine metabolism in the liver of neonatal and adult male offspring.
Lkhagvadorj K, Meyer KF, Verweij LP, Kooistra W, Reinders-Luinge M, Dijkhuizen HW, de Graaf IAM, Plösch T, Hylkema MN. Lkhagvadorj K, et al. Among authors: hylkema mn. Epigenetics. 2020 Dec;15(12):1370-1385. doi: 10.1080/15592294.2020.1782655. Epub 2020 Jun 23. Epigenetics. 2020. PMID: 32573327 Free PMC article.
Pim1 kinase protects airway epithelial cells from cigarette smoke-induced damage and airway inflammation.
de Vries M, Heijink IH, Gras R, den Boef LE, Reinders-Luinge M, Pouwels SD, Hylkema MN, van der Toorn M, Brouwer U, van Oosterhout AJ, Nawijn MC. de Vries M, et al. Among authors: hylkema mn. Am J Physiol Lung Cell Mol Physiol. 2014 Aug 1;307(3):L240-51. doi: 10.1152/ajplung.00156.2013. Epub 2014 May 9. Am J Physiol Lung Cell Mol Physiol. 2014. PMID: 24816488 Free article.
Mouse protocadherin-1 gene expression is regulated by cigarette smoke exposure in vivo.
Koning H, van Oosterhout AJ, Brouwer U, den Boef LE, Gras R, Reinders-Luinge M, Brandsma CA, van der Toorn M, Hylkema MN, Willemse BW, Sayers I, Koppelman GH, Nawijn MC. Koning H, et al. Among authors: hylkema mn. PLoS One. 2014 Jul 3;9(7):e98197. doi: 10.1371/journal.pone.0098197. eCollection 2014. PLoS One. 2014. PMID: 24992194 Free PMC article.
Prenatal exposure to tobacco smoke sex dependently influences methylation and mRNA levels of the Igf axis in lungs of mouse offspring.
Meyer KF, Krauss-Etschmann S, Kooistra W, Reinders-Luinge M, Timens W, Kobzik L, Plösch T, Hylkema MN. Meyer KF, et al. Among authors: hylkema mn. Am J Physiol Lung Cell Mol Physiol. 2017 Apr 1;312(4):L542-L555. doi: 10.1152/ajplung.00271.2016. Epub 2017 Jan 27. Am J Physiol Lung Cell Mol Physiol. 2017. PMID: 28130259 Free article.
Intrauterine smoke exposure deregulates lung function, pulmonary transcriptomes, and in particular insulin-like growth factor (IGF)-1 in a sex-specific manner.
Dehmel S, Nathan P, Bartel S, El-Merhie N, Scherb H, Milger K, John-Schuster G, Yildirim AO, Hylkema M, Irmler M, Beckers J, Schaub B, Eickelberg O, Krauss-Etschmann S. Dehmel S, et al. Sci Rep. 2018 May 15;8(1):7547. doi: 10.1038/s41598-018-25762-5. Sci Rep. 2018. PMID: 29765129 Free PMC article.
Prenatal smoke effect on mouse offspring Igf1 promoter methylation from fetal stage to adulthood is organ and sex specific.
Zeng Z, Meyer KF, Lkhagvadorj K, Kooistra W, Reinders-Luinge M, Xu X, Huo X, Song J, Plösch T, Hylkema MN. Zeng Z, et al. Among authors: hylkema mn. Am J Physiol Lung Cell Mol Physiol. 2020 Mar 1;318(3):L549-L561. doi: 10.1152/ajplung.00293.2019. Epub 2020 Jan 8. Am J Physiol Lung Cell Mol Physiol. 2020. PMID: 31913647 Free article.
110 results