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Page 1
Inflammation induced by influenza virus impairs human innate immune control of pneumococcus.
Jochems SP, Marcon F, Carniel BF, Holloway M, Mitsi E, Smith E, Gritzfeld JF, Solórzano C, Reiné J, Pojar S, Nikolaou E, German EL, Hyder-Wright A, Hill H, Hales C, de Steenhuijsen Piters WAA, Bogaert D, Adler H, Zaidi S, Connor V, Gordon SB, Rylance J, Nakaya HI, Ferreira DM. Jochems SP, et al. Nat Immunol. 2018 Dec;19(12):1299-1308. doi: 10.1038/s41590-018-0231-y. Epub 2018 Oct 29. Nat Immunol. 2018. PMID: 30374129 Free PMC article. Clinical Trial.
Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults.
Nikolaou E, Jochems SP, Mitsi E, Pojar S, Blizard A, Reiné J, Solórzano C, Negera E, Carniel B, Soares-Schanoski A, Connor V, Adler H, Zaidi SR, Hales C, Hill H, Hyder-Wright A, Gordon SB, Rylance J, Ferreira DM. Nikolaou E, et al. mBio. 2021 Jan 12;12(1):e02020-20. doi: 10.1128/mBio.02020-20. mBio. 2021. PMID: 33436429 Free PMC article.
Serotype 3 Experimental Human Pneumococcal Challenge (EHPC) study protocol: dose ranging and reproducibility in a healthy volunteer population (challenge 3).
Hazenberg P, Robinson RE, Farrar M, Solorzano C, Hyder-Wright A, Liatsikos K, Brunning J, Fleet H, Bettam A, Howard A, Kenny-Nyazika T, Urban B, Mitsi E, El Safadi D, Davies K, Lesosky M, Gordon SB, Ferreira DM, Collins AM. Hazenberg P, et al. Among authors: hyder wright a. BMJ Open. 2024 Jan 10;14(1):e075948. doi: 10.1136/bmjopen-2023-075948. BMJ Open. 2024. PMID: 38199622 Free PMC article.
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination.
Mitsi E, Diniz MO, Reiné J, Collins AM, Robinson RE, Hyder-Wright A, Farrar M, Liatsikos K, Hamilton J, Onyema O, Urban BC, Solórzano C, Belij-Rammerstorfer S, Sheehan E, Lambe T, Draper SJ, Weiskopf D, Sette A, Maini MK, Ferreira DM. Mitsi E, et al. Among authors: hyder wright a. Nat Commun. 2023 Oct 26;14(1):6815. doi: 10.1038/s41467-023-42433-w. Nat Commun. 2023. PMID: 37884506 Free PMC article.
A Randomized Controlled Clinical Trial of Nasal Immunization with Live Virulence Attenuated Streptococcus pneumoniae Strains Using Human Infection Challenge.
Hill H, Mitsi E, Nikolaou E, Blizard A, Pojar S, Howard A, Hyder-Wright A, Devin J, Reiné J, Robinson R, Solórzano C, Jochems SP, Kenny-Nyazika T, Ramos-Sevillano E, Weight CM, Myerscough C, McLenaghan D, Morton B, Gibbons E, Farrar M, Randles V, Burhan H, Chen T, Shandling AD, Campo JJ, Heyderman RS, Gordon SB, Brown JS, Collins AM, Ferreira DM. Hill H, et al. Among authors: hyder wright a. Am J Respir Crit Care Med. 2023 Oct 15;208(8):868-878. doi: 10.1164/rccm.202302-0222OC. Am J Respir Crit Care Med. 2023. PMID: 37556679 Clinical Trial.
Comprehensive review of safety in Experimental Human Pneumococcal Challenge.
Robinson RE, Myerscough C, He N, Hill H, Shepherd WA, Gonzalez-Dias P, Liatsikos K, Latham S, Fyles F, Doherty K, Hazenberg P, Shiham F, Mclenghan D, Adler H, Randles V, Zaidi S, Hyder-Wright A, Mitsi E, Burhan H, Morton B, Rylance J, Lesosky M, Gordon SB, Collins AM, Ferreira DM. Robinson RE, et al. Among authors: hyder wright a. PLoS One. 2023 May 4;18(5):e0284399. doi: 10.1371/journal.pone.0284399. eCollection 2023. PLoS One. 2023. PMID: 37141259 Free PMC article. Review.
Human Infection Challenge with Serotype 3 Pneumococcus.
Robinson RE, Mitsi E, Nikolaou E, Pojar S, Chen T, Reiné J, Nyazika TK, Court J, Davies K, Farrar M, Gonzalez-Dias P, Hamilton J, Hill H, Hitchins L, Howard A, Hyder-Wright A, Lesosky M, Liatsikos K, Matope A, McLenaghan D, Myerscough C, Murphy A, Solórzano C, Wang D, Burhan H, Gautam M, Begier E, Theilacker C, Beavon R, Anderson AS, Gessner BD, Gordon SB, Collins AM, Ferreira DM. Robinson RE, et al. Among authors: hyder wright a. Am J Respir Crit Care Med. 2022 Dec 1;206(11):1379-1392. doi: 10.1164/rccm.202112-2700OC. Am J Respir Crit Care Med. 2022. PMID: 35802840
Protocol for a phase IV double-blind randomised controlled trial to investigate the effect of the 13-valent pneumococcal conjugate vaccine and the 23-valent pneumococcal polysaccharide vaccine on pneumococcal colonisation using the experimental human pneumococcal challenge model in healthy adults (PREVENTING PNEUMO 2).
Liatsikos K, Hyder-Wright A, Pojar S, Chen T, Wang D, Davies K, Myerscough C, Reine J, Robinson RE, Urban B, Mitsi E, Solorzano C, Gordon SB, Quinn A, Pan K, Anderson AS, Theilacker C, Begier E, Gessner BD, Collins A, Ferreira DM; PNEUMO 2 study group. Liatsikos K, et al. Among authors: hyder wright a. BMJ Open. 2022 Jul 7;12(7):e062109. doi: 10.1136/bmjopen-2022-062109. BMJ Open. 2022. PMID: 35798520 Free PMC article.
Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization.
Jochems SP, de Ruiter K, Solórzano C, Voskamp A, Mitsi E, Nikolaou E, Carniel BF, Pojar S, German EL, Reiné J, Soares-Schanoski A, Hill H, Robinson R, Hyder-Wright AD, Weight CM, Durrenberger PF, Heyderman RS, Gordon SB, Smits HH, Urban BC, Rylance J, Collins AM, Wilkie MD, Lazarova L, Leong SC, Yazdanbakhsh M, Ferreira DM. Jochems SP, et al. Among authors: hyder wright ad. J Clin Invest. 2022 Jun 1;132(11):e161565. doi: 10.1172/JCI161565. J Clin Invest. 2022. PMID: 35642639 Free PMC article. No abstract available.
25 results