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Anion-exchange chromatography mass spectrometry provides extensive coverage of primary metabolic pathways revealing altered metabolism in IDH1 mutant cells.
Commun Biol. 2020 May 20;3(1):247. doi: 10.1038/s42003-020-0957-6.
Commun Biol. 2020.
PMID: 32433536
Free PMC article.
Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations.
Hvinden IC, Cadoux-Hudson T, Schofield CJ, McCullagh JSO.
Hvinden IC, et al.
Cell Rep Med. 2021 Dec 21;2(12):100469. doi: 10.1016/j.xcrm.2021.100469. eCollection 2021 Dec 21.
Cell Rep Med. 2021.
PMID: 35028610
Free PMC article.
Review.
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Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1.
Liu S, Abboud MI, John T, Mikhailov V, Hvinden I, Walsby-Tickle J, Liu X, Pettinati I, Cadoux-Hudson T, McCullagh JSO, Schofield CJ.
Liu S, et al. Among authors: hvinden i.
Commun Biol. 2021 Nov 1;4(1):1243. doi: 10.1038/s42003-021-02743-5.
Commun Biol. 2021.
PMID: 34725432
Free PMC article.
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Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors.
Reinbold R, Hvinden IC, Rabe P, Herold RA, Finch A, Wood J, Morgan M, Staudt M, Clifton IJ, Armstrong FA, McCullagh JSO, Redmond J, Bardella C, Abboud MI, Schofield CJ.
Reinbold R, et al. Among authors: hvinden ic.
Nat Commun. 2022 Aug 15;13(1):4785. doi: 10.1038/s41467-022-32436-4.
Nat Commun. 2022.
PMID: 35970853
Free PMC article.
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Nuclear Magnetic Resonance Spectroscopy to Identify Metabolite Biomarkers of Nonresponsiveness to Targeted Therapy in Glioblastoma Tumor Stem Cells.
Hvinden IC, Berg HE, Sachse D, Skaga E, Skottvoll FS, Lundanes E, Sandberg CJ, Vik-Mo EO, Rise F, Wilson SR.
Hvinden IC, et al.
J Proteome Res. 2019 May 3;18(5):2012-2020. doi: 10.1021/acs.jproteome.8b00801. Epub 2019 Apr 18.
J Proteome Res. 2019.
PMID: 30964684
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