Huylebroeck D - Search Results

1

Local delivery of hrBMP4 as an anticancer therapy in patients with recurrent glioblastoma: a first-in-human phase 1 dose escalation trial.

Bos EM, Binda E, Verploegh ISC, Wembacher E, Hoefnagel D, Balvers RK, Korporaal AL, Conidi A, Warnert EAH, Trivieri N, Visioli A, Zaccarini P, Caiola L, van Wijck R, van der Spek P, Huylebroeck D, Leenstra S, Lamfers MLM, Ram Z, Westphal M, Noske D, Legnani F, DiMeco F, Vescovi AL, Dirven CMF. Bos EM, et al. Among authors: huylebroeck d. Mol Cancer. 2023 Aug 10;22(1):129. doi: 10.1186/s12943-023-01835-6. Mol Cancer. 2023. PMID: 37563568 Free PMC article. Clinical Trial.

2

The proprotein convertase FURIN is a novel aneurysm predisposition gene impairing TGF-β signaling.

He Z, IJpma AS, Vreeken D, Heijsman D, Rosier K, Verhagen HJM, de Bruin J, Brüggenwirth HT, Roos-Hesselink JW, Bekkers JA, Huylebroeck D, van Beusekom H, Creemers JWM, Majoor-Krakauer D. He Z, et al. Among authors: huylebroeck d. Cardiovasc Res. 2024 Apr 18:cvae078. doi: 10.1093/cvr/cvae078. Online ahead of print. Cardiovasc Res. 2024. PMID: 38636100

3

Type-2 CD8⁺ T-cell formation relies on interleukin-33 and is linked to asthma exacerbations.

van der Ploeg EK, Krabbendam L, Vroman H, van Nimwegen M, de Bruijn MJW, de Boer GM, Bergen IM, Kool M, Tramper-Standers GA, Braunstahl GJ, Huylebroeck D, Hendriks RW, Stadhouders R. van der Ploeg EK, et al. Among authors: huylebroeck d. Nat Commun. 2023 Aug 23;14(1):5137. doi: 10.1038/s41467-023-40820-x. Nat Commun. 2023. PMID: 37612281 Free PMC article.

4

3D chromatin reprogramming primes human memory T_H2 cells for rapid recall and pathogenic dysfunction.

Onrust-van Schoonhoven A, de Bruijn MJW, Stikker B, Brouwer RWW, Braunstahl GJ, van IJcken WFJ, Graf T, Huylebroeck D, Hendriks RW, Stik G, Stadhouders R. Onrust-van Schoonhoven A, et al. Among authors: huylebroeck d. Sci Immunol. 2023 Jul 14;8(85):eadg3917. doi: 10.1126/sciimmunol.adg3917. Epub 2023 Jul 7. Sci Immunol. 2023. PMID: 37418545

5

Zeb2 DNA-Binding Sites in Neuroprogenitor Cells Reveal Autoregulation and Affirm Neurodevelopmental Defects, Including in Mowat-Wilson Syndrome.

Birkhoff JC, Korporaal AL, Brouwer RWW, Nowosad K, Milazzo C, Mouratidou L, van den Hout MCGN, van IJcken WFJ, Huylebroeck D, Conidi A. Birkhoff JC, et al. Among authors: huylebroeck d. Genes (Basel). 2023 Mar 2;14(3):629. doi: 10.3390/genes14030629. Genes (Basel). 2023. PMID: 36980900 Free PMC article.

6

Efficient generation of ETX embryoids that recapitulate the entire window of murine egg cylinder development.

Dupont C, Schäffers OJM, Tan BF, Merzouk S, Bindels EM, Zwijsen A, Huylebroeck D, Gribnau J. Dupont C, et al. Among authors: huylebroeck d. Sci Adv. 2023 Jan 18;9(3):eadd2913. doi: 10.1126/sciadv.add2913. Epub 2023 Jan 18. Sci Adv. 2023. PMID: 36652512 Free PMC article.

7

Identification of candidate enhancers controlling the transcriptome during the formation of interphalangeal joints.

Nowosad K, Brouwer RWW, Odrzywolski A, Korporaal AL, Gielniewski B, Wojtaś B, van IJcken WFJ, Grosveld F, Huylebroeck D, Tylzanowski P. Nowosad K, et al. Among authors: huylebroeck d. Sci Rep. 2022 Jul 27;12(1):12835. doi: 10.1038/s41598-022-16951-4. Sci Rep. 2022. PMID: 35896673 Free PMC article.

8

Comparative single-cell RNA-sequencing profiling of BMP4-treated primary glioma cultures reveals therapeutic markers.

Verploegh ISC, Conidi A, Brouwer RWW, Balcioglu HE, Karras P, Makhzami S, Korporaal A, Marine JC, Lamfers M, Van IJcken WFJ, Leenstra S, Huylebroeck D. Verploegh ISC, et al. Among authors: huylebroeck d. Neuro Oncol. 2022 Dec 1;24(12):2133-2145. doi: 10.1093/neuonc/noac143. Neuro Oncol. 2022. PMID: 35639831 Free PMC article.

9

Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.

Wang J, Farkas C, Benyoucef A, Carmichael C, Haigh K, Wong N, Huylebroeck D, Stemmler MP, Brabletz S, Brabletz T, Nefzger CM, Goossens S, Berx G, Polo JM, Haigh JJ. Wang J, et al. Among authors: huylebroeck d. PLoS Biol. 2021 Sep 22;19(9):e3001394. doi: 10.1371/journal.pbio.3001394. eCollection 2021 Sep. PLoS Biol. 2021. PMID: 34550965 Free PMC article.

10

Low Input Targeted Chromatin Capture (Low-T2C).

Boltsis I, Nowosad K, Brouwer RWW, Tylzanowski P, van IJcken WFJ, Huylebroeck D, Grosveld F, Kolovos P. Boltsis I, et al. Among authors: huylebroeck d. Methods Mol Biol. 2021;2351:165-179. doi: 10.1007/978-1-0716-1597-3_9. Methods Mol Biol. 2021. PMID: 34382189

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