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Tackling gaps in developing life-changing treatments for dementia.
Mauricio R, Benn C, Davis J, Dawson G, Dawson LA, Evans A, Fox N, Gallacher J, Hutton M, Isaac J, Jones DNC, Jones L, Lalli G, Libri V, Lovestone S, Moody C, Noble W, Perry H, Pickett J, Reynolds D, Ritchie C, Rohrer JD, Routledge C, Rowe J, Snyder H, Spires-Jones T, Swartz J, Truyen L, Whiting P; Therapeutics for Dementia Consortium. Mauricio R, et al. Among authors: hutton m. Alzheimers Dement (N Y). 2019 Jun 24;5:241-253. doi: 10.1016/j.trci.2019.05.001. eCollection 2019. Alzheimers Dement (N Y). 2019. PMID: 31297438 Free PMC article. Review.
Astrocytes and neuroinflammation in Alzheimer's disease.
Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ, Noble W. Phillips EC, et al. Biochem Soc Trans. 2014 Oct;42(5):1321-5. doi: 10.1042/BST20140155. Biochem Soc Trans. 2014. PMID: 25233410
Tau: From research to clinical development.
Holtzman DM, Carrillo MC, Hendrix JA, Bain LJ, Catafau AM, Gault LM, Goedert M, Mandelkow E, Mandelkow EM, Miller DS, Ostrowitzki S, Polydoro M, Smith S, Wittmann M, Hutton M. Holtzman DM, et al. Among authors: hutton m. Alzheimers Dement. 2016 Oct;12(10):1033-1039. doi: 10.1016/j.jalz.2016.03.018. Epub 2016 May 4. Alzheimers Dement. 2016. PMID: 27154059 Review.
Altered Synapse Stability in the Early Stages of Tauopathy.
Jackson JS, Witton J, Johnson JD, Ahmed Z, Ward M, Randall AD, Hutton ML, Isaac JT, O'Neill MJ, Ashby MC. Jackson JS, et al. Among authors: hutton ml. Cell Rep. 2017 Mar 28;18(13):3063-3068. doi: 10.1016/j.celrep.2017.03.013. Cell Rep. 2017. PMID: 28355559 Free PMC article.
Clinicopathological features of familial Alzheimer's disease associated with the M139V mutation in the presenilin 1 gene. Pedigree but not mutation specific age at onset provides evidence for a further genetic factor.
Fox NC, Kennedy AM, Harvey RJ, Lantos PL, Roques PK, Collinge J, Hardy J, Hutton M, Stevens JM, Warrington EK, Rossor MN. Fox NC, et al. Among authors: hutton m. Brain. 1997 Mar;120 ( Pt 3):491-501. doi: 10.1093/brain/120.3.491. Brain. 1997. PMID: 9126060
Chromosome 14 familial Alzheimer's disease: the clinical and neuropathological characteristics of a family with a leucine-->serine (L250S) substitution at codon 250 of the presenilin 1 gene.
Harvey RJ, Ellison D, Hardy J, Hutton M, Roques PK, Collinge J, Fox NC, Rossor MN. Harvey RJ, et al. Among authors: hutton m. J Neurol Neurosurg Psychiatry. 1998 Jan;64(1):44-9. doi: 10.1136/jnnp.64.1.44. J Neurol Neurosurg Psychiatry. 1998. PMID: 9436726 Free PMC article.
Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3beta identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes.
Connell JW, Gibb GM, Betts JC, Blackstock WP, Gallo J, Lovestone S, Hutton M, Anderton BH. Connell JW, et al. Among authors: hutton m. FEBS Lett. 2001 Mar 23;493(1):40-4. doi: 10.1016/s0014-5793(01)02267-0. FEBS Lett. 2001. PMID: 11278002 Free article.
480 results