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Page 1
Memory inflation following adenoviral vaccination depends on IL-21.
Gordon CL, Hutchings CL, Highton AJ, Colston JM, Provine NM, Klenerman P. Gordon CL, et al. Among authors: hutchings cl. Vaccine. 2018 Nov 12;36(46):7011-7016. doi: 10.1016/j.vaccine.2018.09.061. Epub 2018 Sep 29. Vaccine. 2018. PMID: 30279090 Free PMC article.
Single-cell transcriptome analysis of CD8 + T-cell memory inflation.
Highton AJ, Zinser ME, Lee LN, Hutchings CL, De Lara C, Phetsouphanh C, Willberg CB, Gordon CL, Klenerman P, Marchi E. Highton AJ, et al. Among authors: hutchings cl. Wellcome Open Res. 2019 May 9;4:78. doi: 10.12688/wellcomeopenres.15115.1. eCollection 2019. Wellcome Open Res. 2019. PMID: 31448339 Free PMC article.
Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern.
Skelly DT, Harding AC, Gilbert-Jaramillo J, Knight ML, Longet S, Brown A, Adele S, Adland E, Brown H; Medawar Laboratory Team; Tipton T, Stafford L, Mentzer AJ, Johnson SA, Amini A; OPTIC (Oxford Protective T cell Immunology for COVID-19) Clinical Group; Tan TK, Schimanski L, Huang KA, Rijal P; PITCH (Protective Immunity T cells in Health Care Worker) Study Group; C-MORE/PHOSP-C Group; Frater J, Goulder P, Conlon CP, Jeffery K, Dold C, Pollard AJ, Sigal A, de Oliveira T, Townsend AR, Klenerman P, Dunachie SJ, Barnes E, Carroll MW, James WS. Skelly DT, et al. Nat Commun. 2021 Aug 17;12(1):5061. doi: 10.1038/s41467-021-25167-5. Nat Commun. 2021. PMID: 34404775 Free PMC article.
A human Phase I/IIa malaria challenge trial of a polyprotein malaria vaccine.
Porter DW, Thompson FM, Berthoud TK, Hutchings CL, Andrews L, Biswas S, Poulton I, Prieur E, Correa S, Rowland R, Lang T, Williams J, Gilbert SC, Sinden RE, Todryk S, Hill AV. Porter DW, et al. Among authors: hutchings cl. Vaccine. 2011 Oct 6;29(43):7514-22. doi: 10.1016/j.vaccine.2011.03.083. Epub 2011 Apr 16. Vaccine. 2011. PMID: 21501642 Free PMC article. Clinical Trial.
Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria.
Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, Bahjat KS, Lauer P, Reyes-Sandoval A, Hutchings CL, Moore AC, Gilbert SC, Hill AV, Bartholomay LC, Harty JT. Schmidt NW, et al. Among authors: hutchings cl. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14017-22. doi: 10.1073/pnas.0805452105. Epub 2008 Sep 9. Proc Natl Acad Sci U S A. 2008. PMID: 18780790 Free PMC article.
Novel genetically-modified chimpanzee adenovirus and MVA-vectored respiratory syncytial virus vaccine safely boosts humoral and cellular immunity in healthy older adults.
Green CA, Sande CJ, Scarselli E, Capone S, Vitelli A, Nicosia A, Silva-Reyes L, Thompson AJ, de Lara CM, Taylor KS, Haworth K, Hutchings CL, Cargill T, Angus B, Klenerman P, Pollard AJ. Green CA, et al. Among authors: hutchings cl. J Infect. 2019 May;78(5):382-392. doi: 10.1016/j.jinf.2019.02.003. Epub 2019 Feb 8. J Infect. 2019. PMID: 30742894 Free PMC article. Clinical Trial.